Treatment of Resistant Auditory Hallucinations in Schizophrenia by Repetitive Transcranial Magnetic Stimulation. Naturalistic Study

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This open naturalistic study aims to evaluate the efficacy of rTMS in routine practice on auditory resistant hallucinations (AHR) of patients with schizophrenia. To this end, two stimulation methods will be offered to patients: the rTMS stimulation method and the cTBS stimulation method.We principally use the AHRS scale to evaluate the effectiveness of rTMS on RAH in patients with schizophrenia. Our main hypothesis is that rTMS used under naturalistic conditions, in addition to antipsychotics, would allow a relative improvement of resistant auditory hallucinations assessed by the AHRS scale between baseline and end of treatment in patients with schizophrenia.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient over 18 years of age

• Patient diagnosed with schizophrenia according to DSM-V criteria (Diagnostic and Statistical Manual of Mental Disorder V5, 2013)

• Presence of auditory hallucinations: Resistant auditory hallucinations: resistance to treatment with 2 different well-conducted antipsychotics.

• Patient agreeing to participate in the study and having signed an informed consent

• Patient with French language skills

• Affiliation to a social security system

• Women of childbearing age must be on contraception and have a negative pregnancy test (βHCG)

Locations
Other Locations
France
Etablissement Public de Santé de Ville-Evrard
RECRUITING
Neuilly-sur-marne
Contact Information
Primary
Youcef Bencherif
urcve1@gmail.com
+33 1 43 09 32 32
Backup
Rusheentira Thavaseelan
urcve1@gmail.com
+33 1 43 09 32 32
Time Frame
Start Date: 2022-07-11
Estimated Completion Date: 2027-11
Participants
Target number of participants: 30
Treatments
Other: The rTMS method
The treatment lasts 2 weeks with 20 rTMS sessions at a rate of 2 sessions per day. Each session lasts 20 minutes with a one hour break between sessions. The application of rTMS will be done on the left temporo-parietal junction.
Other: The cTBS method
The treatment lasts 15 days with 45 sessions of cTBS at a rate of 3 sessions per day. The session lasts 40 seconds and consists of 3 pulses at 50Hz repeated every 200 milliseconds (5Hz) to reach a total of 600 pulses, with a 15 minute break between sessions. The application of cTBS will be performed on the left temporo-parietal junction.
Related Therapeutic Areas
Sponsors
Leads: Dominique JANUEL

This content was sourced from clinicaltrials.gov