Magnetic Seizure Therapy for Schizophrenia - Trial

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This trial aims to assess the clinical effects and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Treatment Resistant Schizophrenia (RS).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• are inpatients or outpatients;

• demonstrate capacity to consent according to the MacArthur competence assessment tool for clinical research (MacCAT-CR);

• have a DSM-5 diagnosis of Schizophrenia or Schizoaffective Disorder for at least 2 years, as determined by the MINI International Neuropsychiatric Interview - Version 7 (MINI-7.0);

• are 18 years of age or older;

• have demonstrated resistance to at least 2 antipsychotics of 600 mg of chlorpromazine equivalents for at least 6 weeks;

• have a BPRS score at baseline of at least moderate severity (\>4) on one of the four psychotic items (i.e., hallucinatory behavior, suspiciousness, conceptual disorganization, unusual thought content) or at least 12 on these 4 items combined;

• are considered to be appropriate to receive convulsive therapy as assessed by an ECT attending psychiatrist and a consultant anaesthesiologist;

• are on an antipsychotic at an adequate dose and are agreeable to keeping their current antipsychotic treatment constant during the acute phase of the intervention;

• are able to adhere to the intervention schedule;

⁃ meet the MST safety criteria;

⁃ If a woman of child-bearing potential: is willing to provide a negative pregnancy test and agrees not to become pregnant during trial participation.

Locations
Other Locations
Canada
Centre for Addiction and Mental Health
RECRUITING
Toronto
University of British Columbia Hospital
RECRUITING
Vancouver
Contact Information
Primary
Daniel Blumberger, MD., MSc.
daniel.blumberger@camh.ca
416-535-8501
Backup
Hannah Taalman, MSc.
hannah.taalman@camh.ca
416-535-8501
Time Frame
Start Date: 2025-04-22
Estimated Completion Date: 2028-11
Participants
Target number of participants: 80
Treatments
Experimental: Magnetic Seizure Therapy (MST)
MST treatments will be administered using the MagPro MST with Cool TwinCoil.
Active_comparator: Electroconvulsive Therapy (ECT)
ECT treatments will be administered using the MECTA spECTrum 5000Q or MECTA Sigma.
Related Therapeutic Areas
Sponsors
Leads: Centre for Addiction and Mental Health
Collaborators: University of British Columbia

This content was sourced from clinicaltrials.gov