Promoting Adaptive Decision-Making in Schizophrenia Through Improved Evidence Integration: A Combined Neuroimaging and Experience Sampling Study

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if attention and ways of thinking impact decision-making and brain processes related to decision-making in people with schizophrenia or schizoaffective disorder relative to people without either condition. It will also learn how brain functioning during decision-making relates to real-world decisions made during daily life. The main questions it aims to answer are: * Does paying attention to specific information impact decision-making and brain processes? * Does thinking in a certain way according to specific 'thinking strategies' improve brain processes related to decision-making? * Does brain functioning during decision-making relate to real-world choices to engage in activities? Researchers will compare brain functioning and decision-making on computer tasks of gambling after participants have been trained to use a positive thinking strategy. They will compare what is different in the brain and behavior when participants use this strategy and when they do not. Participants will also answer brief surveys about activities and feelings for a week in their daily lives. Participants will: * Complete several hours of clinical interviewing, cognitive tests, and surveys of about symptoms, experiences, and personality * Complete computer tasks about gambling decisions during MRI brain scanning and while having their visual attention measured using eye-tracking * Complete brief surveys about their activities and feelings 5 times a day for 1 week using a cell phone. Each survey only take several minutes.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:

⁃ The following criteria apply to all subjects:

• Between ages of 18-45.

• Have capacity to provide informed consent

• Fluent communication in English

• Willingness and ability to follow study requirements, as evidenced by an ability to provide written or virtual informed consent and read, and complete, study procedures.

• Cognitive ability to understand tasks and estimated IQ greater than 70.

⁃ The following criteria apply to subjects with schizophrenia:

⁃ 1\. Primary diagnosis of schizophrenia or schizoaffective disorder

⁃ The following additional criteria apply to subjects without schizophrenia:

⁃ 1\. Inclusion based on subject matched to psychiatric group based on age, sex, race/ethnicity, and education level.

Locations
United States
New Jersey
Center for Advanced Human Brain Imaging Research
RECRUITING
Piscataway
Contact Information
Primary
Pariya Chanthasensack, BS
CANL@rwjms.rutgers.edu
732-235-6438
Backup
John Purcell, PhD
jrp345@rwjms.rutgers.edu
732-235-6438
Time Frame
Start Date: 2025-01-07
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 74
Treatments
Experimental: Single Arm
There is only 1 arm in this study. In this arm of the study, participants are instructed to implement a cognitive strategy (i.e., way of thinking) during 1/2 of the trials of a behavioral, gambling task. On the other 1/2 of the trials they behave naturally without implementing the cognitive strategy.
Related Therapeutic Areas
Sponsors
Leads: Rutgers, The State University of New Jersey
Collaborators: National Institute of Mental Health (NIMH)

This content was sourced from clinicaltrials.gov