A Randomized Controlled EEG-GSR Study on the Effects of Cognitive Remediation Therapy on Neurophysiological and Emotional Regulation Markers in Schizophrenia

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study aims to determine whether Cognitive Remediation Therapy (CRT) can improve attention, memory, and emotional regulation in people with schizophrenia. CRT is a structured program that includes exercises to strengthen cognitive skills such as problem-solving, working memory, and emotion regulation. The study will recruit 60 participants: 30 individuals with schizophrenia and 30 healthy individuals of similar age and gender. Those with schizophrenia will be randomly assigned to either receive CRT or be placed on a waitlist without therapy. All participants will undergo non-invasive brain activity (EEG) and emotional response (GSR) recordings before and after the therapy. The study's main question is: Does participating in a 12-week CRT program improve brain-based markers of attention and emotional regulation in people with schizophrenia? Additional tests, such as memory and emotion recognition tasks and self-report questionnaires, will help assess changes in thinking skills and emotional well-being. The study may help better understand how CRT affects both brain function and quality of life in schizophrenia.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: t
View:

• Diagnosed with schizophrenia according to DSM-5 criteria

• Age between 18 and 55 years

• Clinically stable (no hospitalization or medication change within 1 month)

• Minimum primary school education

• Able to provide informed consent

• Right-handed (for EEG protocol consistency)

• No history of psychiatric or neurological disorders

• Age- and gender-matched to schizophrenia group

• No current medication affecting CNS

• Able to provide informed consent

• Right-handed

Locations
Other Locations
Turkey
Beykoz University
RECRUITING
Istanbul
Contact Information
Primary
Eda Yılmazer, Phd
edayilmazer@beykoz.edu.tr
00905322575880
Backup
Metin Çınaroğlu, Phd
metincinaroglu@gmail.com
00905324732070
Time Frame
Start Date: 2025-03-15
Estimated Completion Date: 2025-10-15
Participants
Target number of participants: 60
Treatments
Experimental: CRT Group
Participants with schizophrenia assigned to receive 12 sessions of Cognitive Remediation Therapy (CRT) over 12 weeks. Each session lasts approximately 60 minutes and targets cognitive domains including attention, working memory, executive function, and emotion regulation.
No_intervention: Waitlist Control
Participants with schizophrenia assigned to a waitlist control group. They will not receive any therapy during the 12-week period but will undergo baseline and post-assessments similar to the CRT group.
Related Therapeutic Areas
Sponsors
Collaborators: Uskudar University, Istanbul Nisantasi University
Leads: Beykoz University

This content was sourced from clinicaltrials.gov