Investigation of Clinical, Cognitive and Neurophysiological Markers, Possibly Specific of Two Subforms of Psychotic Disorders

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The current diagnostic criteria for schizophrenia and other psychotic disorders are relatively broad and lack precision. Therefore, distinct diseases may be grouped together under the same diagnostic category, although these diseases may differ according to their clinical expression, prognosis and perhaps their physiopathological causes. We think that identifying subforms of psychotic disorders that are more homogeneous will better enable to understand their respective physiopathological causes and find personalized treatments. This study will compare two subforms of psychotic disorders that have been clinically distinguished in the 1970s. These phenotypes have however not been validated yet using scientific investigations. Using clinical assessments, cognitive evaluations and neurophysiological measures (fMRI) investigating the domains of affect and psychomotoricity , we expect that these two subforms will differ on their clinical, cognitive and neurophysiological characteristics, namely: hebephrenia will be associated with deficits on the affect markers , and respect psychomotoricity (catatonia scales, tests assessing movement planification) whereas the opposite pattern will be observed for periodic catatonia.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
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• for both patients and controls

• male or female willing to participate and who have signed up the legal document

• under the protection of health insurance for patients only

• schizophrenia or schizo-affective disorder according to the DSM-5 criteria

• periodic catatonia or hebephrenia accordin to WKL classification

• clinically stable for at least 2 months

• in or out patients for controls only

• no psychiatric history

Locations
Other Locations
France
Service de Psychiatrie I, Hôpital Civil, Hôpitaux Universitaires de Strasbourg
RECRUITING
Strasbourg
Contact Information
Primary
Fabrice BERNA, MD
fabrice.berna@chru-strasbourg.fr
03 88 11 64 62
Time Frame
Start Date: 2019-02-28
Estimated Completion Date: 2027-02-02
Participants
Target number of participants: 84
Treatments
Experimental: patient with schizophrenia and periodic catatonia
Experimental: patient with schizophrenia and hebephrenia
Active_comparator: healthy volunteers
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Strasbourg, France

This content was sourced from clinicaltrials.gov