SchwannomatosisSymptoms, Doctors, Treatments, Advances & More
Learn About Schwannomatosis
View Main Condition: Neural Crest Tumor
Schwannomatosis is a disorder characterized by multiple noncancerous (benign) tumors called schwannomas, which are a type of tumor that grows on nerves. Schwannomas develop when Schwann cells, which are specialized cells that normally form an insulating layer around the nerve, grow uncontrollably to form a tumor.
Mutations in at least two genes, SMARCB1 and LZTR1, can cause schwannomatosis. The proteins produced from both genes are thought to act as tumor suppressors, which normally keep cells from growing and dividing too rapidly or in an uncontrolled way. Mutations in either of these genes may help cells grow and divide without control or order to form a tumor.
The incidence of schwannomatosis is unknown, although estimates in several populations have ranged from 1 in 40,000 to 1 in 1.7 million people. Some researchers have suggested that schwannomatosis may be as common as neurofibromatosis type 2, which has an incidence of 1 in 33,000 people worldwide.
Most cases of schwannomatosis are sporadic, which means that they occur in people with no history of the disorder in their family. Some people with sporadic schwannomatosis have mutations in the SMARCB1 or LZTR1 gene, but in others, the cause of the condition is unknown.
Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville
Jaishri Blakeley is a Neurologist practicing medicine in Lutherville, Maryland. Dr. Blakeley is rated as an Elite provider by MediFind in the treatment of Schwannomatosis. She is also highly rated in 27 other conditions, according to our data. Her clinical expertise encompasses Neurofibromatosis, Schwannomatosis, Neurofibromatosis Type 2 (NF2), Neurofibromatosis Type 1 (NF1), and Laminectomy. Dr. Blakeley is board certified in American Board Of Psychiatry And Neurology. Dr. Blakeley is currently accepting new patients.
Dafydd Evans practices practicing medicine in Manchester, United Kingdom. Evans is rated as an Elite expert by MediFind in the treatment of Schwannomatosis. They are also highly rated in 38 other conditions, according to our data. Their clinical expertise encompasses Schwannomatosis, Neurofibromatosis Type 2 (NF2), Acoustic Neuroma, Oophorectomy, and Salpingo-Oophorectomy.
Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville
Allan Belzberg is a General Surgeon and a Neurosurgery provider practicing medicine in Lutherville, Maryland. He has been practicing medicine for over 44 years. Dr. Belzberg is rated as an Elite provider by MediFind in the treatment of Schwannomatosis. He is also highly rated in 20 other conditions, according to our data. His clinical expertise encompasses Schwannomatosis, Neurofibromatosis, Schwannoma, Rhizotomy, and Laminectomy. Dr. Belzberg is board certified in American Board Of Neurological Surgery. Dr. Belzberg is currently accepting new patients.
Summary: This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a ...
Summary: This is a placebo-controlled, multi-arm phase II platform screening trial designed to test the safety, pain responses, and pharmacodynamic activity of multiple experimental therapies simultaneously in participants with moderate-to-severe pain due to schwannomatosis (SWN). This Master Study is being conducted as a platform that may allow participants with pain associated with schwannomatosis to rec...
Published Date: January 01, 2017
Published By: National Institutes of Health