Learn About Schwannomatosis

What is the definition of Schwannomatosis?

Schwannomatosis is a disorder characterized by multiple noncancerous (benign) tumors called schwannomas, which are a type of tumor that grows on nerves. Schwannomas develop when Schwann cells, which are specialized cells that normally form an insulating layer around the nerve, grow uncontrollably to form a tumor.

Save information for later
Sign Up
What are the causes of Schwannomatosis?

Mutations in at least two genes, SMARCB1 and LZTR1, can cause schwannomatosis. The proteins produced from both genes are thought to act as tumor suppressors, which normally keep cells from growing and dividing too rapidly or in an uncontrolled way. Mutations in either of these genes may help cells grow and divide without control or order to form a tumor.

How prevalent is Schwannomatosis?

The incidence of schwannomatosis is unknown, although estimates in several populations have ranged from 1 in 40,000 to 1 in 1.7 million people. Some researchers have suggested that schwannomatosis may be as common as neurofibromatosis type 2, which has an incidence of 1 in 33,000 people worldwide.

Is Schwannomatosis an inherited disorder?

Most cases of schwannomatosis are sporadic, which means that they occur in people with no history of the disorder in their family. Some people with sporadic schwannomatosis have mutations in the SMARCB1 or LZTR1 gene, but in others, the cause of the condition is unknown.

Who are the top Schwannomatosis Local Doctors?
Elite
Highly rated in
39
conditions
Neurology

Mass General Brigham

Pappas Center For Neuro Oncology

55 Fruit St 
Boston, MA 2114

Scott Plotkin is a Neurologist in Boston, Massachusetts. Dr. Plotkin has been practicing medicine for over 24 years and is rated as an Elite doctor by MediFind in the treatment of Schwannomatosis. He is also highly rated in 39 other conditions, according to our data. His top areas of expertise are Neurofibromatosis, Schwannomatosis, Neurofibromatosis Type 2, and Neurofibromatosis Type 1. He is licensed to treat patients in Massachusetts. Dr. Plotkin is currently accepting new patients.

Elite
Highly rated in
32
conditions
Neurology

Johns Hopkins Health System

The Johns Hopkins Hospital

600 N Wolfe St 
Baltimore, MD 21287

Jaishri Blakeley is a Neurologist in Baltimore, Maryland. Dr. Blakeley has been practicing medicine for over 21 years and is rated as an Elite doctor by MediFind in the treatment of Schwannomatosis. She is also highly rated in 32 other conditions, according to our data. Her top areas of expertise are Neurofibromatosis, Neurofibromatosis Type 1, Schwannomatosis, and Neurofibromatosis Type 2. She is licensed to treat patients in Maryland. Dr. Blakeley is currently accepting new patients.

 
 
 
 
Learn about our expert tiers
Learn more
Elite
Highly rated in
26
conditions
Neurology

Mass General Brigham

Mass General/North Shore Cancer Center

102 Endicott St 
Danvers, MA 1923

Justin Jordan is a Neurologist in Danvers, Massachusetts. Dr. Jordan has been practicing medicine for over 13 years and is rated as an Elite doctor by MediFind in the treatment of Schwannomatosis. He is also highly rated in 26 other conditions, according to our data. His top areas of expertise are Neurofibromatosis, Schwannomatosis, Neurofibromatosis Type 2, and Neurofibromatosis Type 1. He is licensed to treat patients in Massachusetts. Dr. Jordan is currently accepting new patients.

What are the latest Schwannomatosis Clinical Trials?
Clinical Investigation to Evaluate the CONVIVO System for Discrimination of Normal From Abnormal Tissue During Brain Tumor Resection
Match to trials
Find the right clinical trials for you in under a minute
Get started
Prospective Study : Long-term Evolution of Balance and Vestibular Function in Patients Treated With Gammaknife Radiosurgery for Vestibular Schwannoma EQUI-GAMMA
Who are the sources who wrote this article ?

Published Date: January 01, 2017Published By: National Institutes of Health

What are the Latest Advances for Schwannomatosis?
Stereotactic radiosurgery for hypoglossal schwannoma.
Peripheral schwannomas of the tibial nerve: surgical results in a case series.
Tired of the same old research?
Check Latest Advances
Successful treatment of pancreatic schwannoma by enucleation: A case report.