• Age: 18\

‣ 65 years old

• Diagnosis of B-cell mediated autoimmune rheumatic diseases - SLE, SSc, IIM, RA.

• Expected survival period ≥ 3 months;

• Serum creatinine \<221.0μmol/L (2.5mg/dl);

• AST/ALT below 3 times the upper limit of normal, blood bilirubin \<34.2 μmol/L (2.0 mg/dl);

• Cardiopulmonary function is basically normal, echocardiography indicates that the ejection fraction is \>45%, normal to mild pulmonary hypertension, and the oxygen saturation is above 93% in the resting state without oxygen;

• No obvious active infection;

• Physical fitness score 0\

‣ 2 points (ECOG standard);

• There are suitable veins for blood cell apheresis or whole blood collection, and there are no contraindications for blood collection;

⁃ Women of childbearing age should have a negative serum or urine pregnancy test 48 hours before CAR T cell reinfusion, and agree to take effective contraceptive measures during the trial until the last follow-up;

⁃ Voluntary participation and informed consent signed by the patient or his/her legal/authorized representative;