Sengers Syndrome
Symptoms, Doctors, Treatments, Advances & More

Sengers Syndrome Overview

Save information for later
Sign Up

Learn About Sengers Syndrome

View Main Condition: Cardiomyopathy

What is the definition of Sengers Syndrome?
Sengers syndrome is a rare autosomal recessive mitochondrial (cells that create energy) depletion disorder that causes a loss of function of the acylglycerol kinase (AGK) gene that is responsible for maintaining mitochondrial DNA, resulting in infants that are born with congenital cataracts, hypertrophic cardiomyopathy (thickening of heart muscle; HOCM), skeletal myopathy, and lactic acidosis.
What are the symptoms of Sengers Syndrome?
The hallmark symptom of Sengers syndrome is the appearance of congenital cataracts in an infant in the first few weeks of life, along with the development of progressive hypertrophic cardiomyopathy (thickening of heart muscle and heart failure), skeletal myopathy, and lactic acidosis. Additional symptoms may include generalized hypotonia (lack of muscle tone), exercise intolerance, and delayed motor development. Some children with Sengers syndrome may have mental retardation.
Not sure about your diagnosis?
Check Your Symptoms
What are the current treatments for Sengers Syndrome?
If untreated, the progressive hypertrophic cardiomyopathy associated with Sengers syndrome can be fatal in the first few weeks of life. Some patients may be treated with heart transplantation. The cataracts associated with Sengers syndrome may require surgical removal. Children with Sengers syndrome may have normal mental development if the lactic acidosis is treated with oxygen and intravenous fluids.
Who are the top Sengers Syndrome Local Doctors?
Distinguished in Sengers Syndrome
Distinguished in Sengers Syndrome
Referral may be required
675 N St Clair St Ste 19-100, Galter Pavilion, 
Chicago, IL 
312-664-3278
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Lubna Choudhury is a Cardiologist practicing medicine in Chicago, Illinois. Dr. Choudhury is rated as a Distinguished provider by MediFind in the treatment of Sengers Syndrome. She is also highly rated in 13 other conditions, according to our data. Her clinical expertise encompasses Hypertrophic Cardiomyopathy (HCM), Cardiomyopathy, Subvalvular Aortic Stenosis, Familial Hypertrophic Cardiomyopathy, and Cardiac Ablation. Dr. Choudhury is board certified in American Board Of Internal Medicine - Cardiovascular Disease (Certified). Dr. Choudhury is currently accepting new patients.

Distinguished in Sengers Syndrome
Distinguished in Sengers Syndrome
Referral may be required

Duke Cardiology Arringdon

5601 Arringdon Park Dr, 
Morrisville, NC 
919-997-3100
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Andrew Wang is a Cardiologist practicing medicine in Morrisville, North Carolina. Dr. Wang is rated as a Distinguished provider by MediFind in the treatment of Sengers Syndrome. He is also highly rated in 13 other conditions, according to our data. His clinical expertise encompasses Familial Hypertrophic Cardiomyopathy, Sengers Syndrome, Subvalvular Aortic Stenosis, Heart Valve Repair, and Transcatheter Aortic Valve Replacement (TAVR). Dr. Wang is board certified in American Board Of Internal Med, Cardiovascular Disease. Dr. Wang is currently accepting new patients.

 
 
 
 
Learn about our expert tiers
Learn More
Distinguished in Sengers Syndrome
Distinguished in Sengers Syndrome
Referral may be required

Ascension Saint Thomas Heart West - Comprehensive Cardiomyopathy Center

4230 Harding Pike, Ste 330, 
Nashville, TN 
615-222-4265
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Mark Zenker is a Cardiologist practicing medicine in Nashville, Tennessee. Dr. Zenker is rated as a Distinguished provider by MediFind in the treatment of Sengers Syndrome. He is also highly rated in 22 other conditions, according to our data. His clinical expertise encompasses Familial Hypertrophic Cardiomyopathy, Hypertrophic Cardiomyopathy (HCM), Sengers Syndrome, Pacemaker Implantation, and Cardiac Ablation. Dr. Zenker is board certified in The American Board Of Internal Medicine - Cardiovascular Disease and National Board Of Echocardiography - Adult Echocardiography. Dr. Zenker is currently accepting new patients.

View All Doctors
What are the latest Sengers Syndrome Clinical Trials?
Match to trials
Find the right clinical trials for you in under a minute
Get started
View All Clinical Trials