Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure, despite lots of intravenous fluids. The incidence of septic shock related cardiomyopathy was 10% to 70%. Besides, general anesthesia will inhibit the sympathetic nervous system, reduce myocardial contractility and aggravate cardiac dysfunction. No randomized controlled trials have yet explore the effects of dobutamine on clinical outcomes for patients with septic shock undergoing surgery under general anesthesia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients with 18 years or older
• Sugery patients with septic shock and the duration of opration is more than 1 hour
Locations
Other Locations
China
The First Affiliated Hospital, School of Medicine, Zhejiang University
RECRUITING
Hangzhou
Contact Information
Primary
Xiangming Fang, Doctor
xmfang@zju.edu.cn
13867161019
Time Frame
Start Date: 2024-05-09
Estimated Completion Date: 2027-04-30
Participants
Target number of participants: 584
Treatments
Experimental: Dobutamine, norepinephrine
Patients will be initiated on Dobutamine at 5 mcg/kg/min while continuous infusion of norepinephrine titrated to maintain a mean arterial pressure at 65mmHg or more
Other: Norepinephrine
Norepinephrine was titrated to maintain a mean arterial pressure at 65mmHg or more
Related Therapeutic Areas
Sponsors
Collaborators: Fujian Provincial Hospital, Weifang People's Hospital, Central Hospital of Heng Yang, Ningbo No. 1 Hospital, The First Clinical College of Harbin University, Huaibei Peolple's Hospital, Zhejiang Provincial People’s Hospital, Wuhan Third Hospital, Union hospital of Fujian Medical University, Guizhou Provincial People's Hospital, First Affiliated Hospital of Shenzhen University, Zhejiang Cancer Hospital, Lishui Country People's Hospital, First Affiliated Hospital of Xinjiang Medical University, Tongji Hospital, Southwest Hospital, China, Renmin Hospital of Wuhan University, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Affiliated Hospital of Jiaxing University, The Second Hospital of Hebei Medical University, Affiliated Hospital of Guangdong Medical University, Weihai Municipal Hospital, The First Affiliated Hospital of Shihezi University Medical College, Ningbo No.2 Hospital, Fuyang Hospital of Anhui Medical University, Anqing People's Hospital of Anhui Medical University, Wenzhou people's hospital，zhejiang province,China, The First People's Hospital of Zunyi, The Hospital of Suixi County, Zhujiang Hospital, Bijie Hospital of Zhejiang Provincial People's Hospital, The First Affiliated Hospital of Zhengzhou University, Henan Provincial People's Hospital, The First Affiliated Hospital of University of South China, The First Affiliated Hospital of Soochow University, The Second Hospital University of South China, Tianjin Medical University General Hospital, The First Affiliated Hospital of Anhui Medical University, Red Cross Hospital, Hangzhou, China, Zhejiang Provincial Tongde Hospital, Zunyi Medical College, The Central Hospital of Lishui City, People's Hospital of Xinjiang Uygur Autonomous Region
Leads: First Affiliated Hospital of Zhejiang University