Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
* Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome. * Describing immuno-inflammatory profiles associated with massive vascular leakage during those three forms of circulatory failure in humans
• Informed consent from patient or a legal representative/family member/close relative. The patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow.
• Affiliation to social security (AME excluded)
• Patient with one of the circulatory failures described below:
‣ septic shock
⁃ cardiogenic shock
⁃ post-resuscitation syndrome
⁃ Cardiogenic shock:
• Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND
∙ Cardiac index \<2 L/min/m2 or left ventricular ejection fraction (LVEF)\<35%, AND
∙ Lactate \>2.0 mmol/l
⁃ Post-resuscitation syndrome:
• Cardiac arrest (absence of spontaneous respiration, palpable heartbeat, and responsiveness to stimuli\> 1 min) with a compatible electrocardiogram (asystole/pulseless electrical activity/ventricular tachycardia), AND
∙ Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND
∙ Lactate \>2.0 mmol/l
⁃ Septic shock:
• Suspected or proven bacterial infection
∙ Need for a vasopressor support to maintain mean arterial pressure\>65 mmHg
∙ Lactate \>2.0 mmol/l
∙ Cardiac index\>3L/min/m2 or LVEF\>40%