Clinical Utility of Longitudinal Measurement of Hemodynamic Incoherence and Endothelial

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future resuscitation trials. We will serially evaluate microhemodynamics (MiH) and macro hemodynamics (maH) and the perfused boundary region (PBR, an visual proxy for eGC thickness) using HVM, and a validated circulating biomarker of eGC integrity.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 99
Healthy Volunteers: t
View:

⁃ Septic Patient Cohort:

• Greater than or equal to 18 years of age

• Diagnosed with sepsis or septic shock

• Require admission to the Hospital

⁃ Control Cohort:

• Greater than or equal to 18 years of age

• Undergoing elective surgery requiring intubation and general anesthesia

Locations
United States
Colorado
Denver Health Medical Center
RECRUITING
Denver
Contact Information
Primary
August Longino, MD
August.longino@cuanschutz.edu
801-903-3258
Backup
Terra Hiller, MSN, RN
Terra.Hiller@dhha.org
720-602-1438
Time Frame
Start Date: 2022-07-01
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 150
Treatments
Other: Septic Patient Interventions
Septic Patients will have all interventions performed: Urine collection, Passive Leg Raise, Ultrasound and sublingual microscopy
Other: Control Patient Interventions
Control patients will have urine collection and sublingual microscopy performed when intubated
Related Therapeutic Areas
Stroke
Sepsis
Sponsors
Leads: Denver Health and Hospital Authority
Collaborators: National Institutes of Health (NIH)

This content was sourced from clinicaltrials.gov

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