Latest Advances

  • Condition: Nephrotic Syndrome in Sickle Cell Disease (SCD)
  • Journal: BMJ case reports
  • Treatment Used: Hydroxyurea and Anti-ACE Inhibitors (ACEis)
  • Number of Patients: 1
  • Published —
This case report describes a female adolescent with sickle cell disease (SCD) diagnosed with nephrotic syndrome (protein in urine) treated with corticosteroids, hydroxyurea, and anti-ACE inhibitors (ACEis).
  • Condition: Sickle Cell Disease
  • Journal: Blood advances
  • Treatment Used: Allogeneic Stem Cell Transplantation with Omidubicel
  • Number of Patients: 13
  • Published —
This study tested the safety and efficacy of using allogeneic stem cell transplantation with omidubicel to treat patients with sickle cell disease.
  • Condition: Sickle Cell Disease and Thalassemia
  • Journal: Blood advances
  • Treatment Used: Stem Cell Transplant or Gene Therapy
  • Number of Patients: 517
  • Published —
This systematic review evaluated the quality of life in patients with sickle cell disease (SCD) and thalassemia after treatment with hematopoietic stem cell transplant (HSCT) or gene therapy.
  • Condition: Sickle Cell Disease (SCD) and ?-Thalassemia
  • Journal: The New England journal of medicine
  • Treatment Used: CRISPR-Cas9 Gene Editing
  • Number of Patients: 2
  • Published —
This case report describes the use of CRISPR-Cas9 gene editing in the treatment of patients with transfusion-dependent ?-thalassemia (TDT) and sickle cell disease (SCD).
  • Condition: Sickle Cell Disease
  • Journal: The New England journal of medicine
  • Treatment Used: Post-Transcriptional Genetic Silencing of BCL11A
  • Number of Patients: 6
  • Published —
This study investigated the use of post-transcriptional genetic silencing of BCL11A in the treatment of patients with sickle cell disease.
  • Condition: Osteonecrosis of the Femoral Head
  • Journal: Journal of biological regulators and homeostatic agents
  • Treatment Used: Total Hip Replacement
  • Number of Patients: 12
  • Published —
In this study, researchers evaluated the outcomes of undergoing total hip replacement for the treatment of osteonecrosis of the femoral head in patients with sickle cell disease.
  • Condition: Sickle Cell Disease
  • Journal: The Lancet. Haematology
  • Treatment Used: Hematopoietic Stem Cell Transplantation (HSCT)
  • Number of Patients: 0
  • Published —
This article discusses the role of hematopoietic stem cell transplantation (HSCT) for sickle cell disease in the era of targeted disease-modifying therapies and gene editing.
  • Condition: Acute Graft-versus-Host Disease in Children
  • Journal: Frontiers in immunology
  • Treatment Used: Mesenchymal Stromal Cells
  • Number of Patients: 0
  • Published —
The study researched the use of mesenchymal stromal cells for treating acute graft-versus-host disease in children.
  • Condition: Children and Adolescents with Sickle Cell Anemia (SCA)
  • Journal: Scientific reports
  • Treatment Used: Hydroxyurea Treatment
  • Number of Patients: 87
  • Published —
This study evaluated the effectiveness of hydroxyurea treatment in children and adolescents with sickle cell anemia (disease in which the body produces abnormally shaped red blood cells that have a crescent or sickle shape; SCA).
  • Condition: Children with Pain and Sickle Cell Anemia
  • Journal: American journal of hematology
  • Treatment Used: Arginine Therapy
  • Number of Patients: 68
  • Published —
The study researched the outcomes of arginine therapy for children hospitalized for pain from sickle cell anemia.
  • Condition: Sickle Cell Disease
  • Journal: Cells
  • Treatment Used: Hydroxyurea (HU)
  • Number of Patients: 0
  • Published —
This study characterized hematopoiesis in sickle cell disease and the role of hydroxyurea (HU) treatment.
  • Condition: Sickle Cell Disease
  • Journal: The Cochrane database of systematic reviews
  • Treatment Used: Phytomedicines
  • Number of Patients: 212
  • Published —
The study researched the outcomes of phytomedicines for sickle cell disease.
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