The Treatment of Transcranial Alternating Current Stimulation（tACS）on Patients With Cerebellar Ataxia: A Randomized, Triple-blind, Parallel-controlled Study
This is a longitudinal, triple-blind, randomized-controlled, prospective interventional study assessing patients with cerebellar ataxia, including spinocerebellar ataxia type 3 (SCA3) and multiple system atrophy-cerebellar type (MSA-C), to examine the efficacy, safety, and tolerability of transcranial alternating current stimulation (tACS) for up to 3 months.
• for SCA3
‣ Patients with detectable clinical signs and confirmed genetic diagnosis with SCA3
⁃ SCA3 patients aged 18 - 80 years
⁃ Patients or their family members have informed consent to the study and signed relevant documents
⁃ The pre-study ataxia Assessment Score (SARA) ranged from 3 to 30
• for MSA-C
‣ Aged 30-80 years
⁃ Diagnosed as clinically determined (Established)MSA-C or clinically Probable MSA-C according to the latest MSA diagnostic criteria
⁃ No more than 8 years after diagnosis of MSA-C
⁃ Able to walk independently or with assistance
⁃ Have a life expectancy of at least 3 years
⁃ Women of childbearing age with MSA need to use contraceptive measures