Assessment of Adults Epidemiological Characteristics of Status Epilepticus in the French West Indies and in French Guiana

Status: Recruiting
Location: See all (4) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

The justification of this prospective and multicenter study is based on the absence of published data concerning, status epilepticus (SE), a pathology which seems frequent in the French West Indies (FWI) and French Guiana, and whose etiological and prognostic characteristics are often mentioned or assumed but which remain to be demonstrated. The scientific interest lies both in the knowledge of the epidemiology of this pathology and in the identification of the main etiologies, in particular the underlying brain lesions. The morbidity of SE is significant, associating neurological disorders with impaired consciousness, respiratory, hemodynamic and cardiac rhythm disorders, as well as metabolic disorders such as acidosis. SE-related mortality in the acute phase ranges from 3-40% across studies and regions, while long-term mortality ranges from 17-80% depending on age, cause of SE, comorbidities and the occurrence of complications. The prognosis of this pathology has however improved in recent years in developed countries or countries with a high level of health system. On the other hand, the morbidity and mortality of SE in the French overseas departments is not known, even if these territories are supposed to be at an equivalent level in terms of health system to that of mainland France.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult patients (≥ 18 years old) treated for SE by SAMU/SMUR and by emergencies or intensive care in the French West Indies and French Guiana.

• Covered for suspected or SE diagnosis defined by one of the following:

‣ a prolonged generalized tonic-clonic crisis lasting more than 5 minutes and accompanied by impaired consciousness or at least 2 generalized tonic-clonic crisis without return to normal consciousness between crisis.

⁃ a focal convulsive crisis (motor or not) with disturbances of consciousness which lasts beyond 10 minutes or crisis which are repeated (≥ 2) at short intervals without recovery of interictal consciousness.

⁃ a focal convulsive crisis (motor or not) without alteration of consciousness that lasts beyond 10 to 15 minutes.

⁃ an absence-type crisis that lasts longer than 10 to 15 minutes.

⁃ a myoclonic, clonic and tonic crisis that lasts longer than 10 to 15 minutes.

⁃ a coma with an epileptic cause diagnosed on an EEG.

• Patient if he is able to, or representative of the patient in case of incapacity, having given his agreement for the use of his medical data for this research.

Locations
Other Locations
France
Hospital of Basse-Terre
NOT_YET_RECRUITING
Basse-terre
Hospital of Cayenne
RECRUITING
Cayenne
University Hospital Center of Martinique
RECRUITING
Fort-de-france
University Hospital Center of Guadeloupe
NOT_YET_RECRUITING
Pointe À Pitre
Contact Information
Primary
Florian Negrello, MD
florian.negrello@chu-martinique.fr
05 96 55 20 15
Backup
Papa Gueye, PhD
papa.gueye@chu-martinique.fr
Time Frame
Start Date: 2022-05-15
Estimated Completion Date: 2025-01-30
Participants
Target number of participants: 241
Treatments
Subjects covered for suspected or SE diagnosis
Patients covered for suspected or SE diagnosis defined by one of the following:~* a prolonged generalized tonic-clonic crisis lasting more than 5 minutes and accompanied by impaired consciousness or at least 2 generalized tonic-clonic crisis without return to normal consciousness between crisis.~* a focal convulsive crisis (motor or not) with disturbances of consciousness which lasts beyond 10 minutes or crisis which are repeated (≥ 2) at short intervals without recovery of interictal consciousness.~* a focal convulsive crisis (motor or not) without alteration of consciousness that lasts beyond 10 to 15 minutes.~* an absence-type crisis that lasts longer than 10 to 15 minutes.~* a myoclonic, clonic and tonic crisis that lasts longer than 10 to 15 minutes.~* a coma with an epileptic cause diagnosed on an EEG.
Related Therapeutic Areas
Sponsors
Leads: University Hospital Center of Martinique

This content was sourced from clinicaltrials.gov