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Recovery From Post-Stroke Aphasia With rTMS Targeting the Anterior Temporal Lobe: Interhemispheric Activation Changes and Lesion-Connectome-Based Predictive Outcomes

Status: Recruiting

Location: See location...

Intervention Type: Behavioral, Device

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Healthy Volunteers: f

View:

• Right-handedness (assesed using the Edinburgh Handedness Inventory)

• Native English speakers

• Single left hemispheric stroke

• Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician

Locations

United States

South Carolina

McCausland Center

RECRUITING

Columbia

Contact Information

Primary

Sophie Arheix-Parras, PhD

sophie.arheix-parras@sc.edu

803-467-8018

Time Frame

Start Date: 2026-05-15

Estimated Completion Date: 2027-07-30

Participants

Target number of participants: 45

Treatments

Experimental: Inhibitory rTMS

Participants will receive inhibitory continuous Theta Burst Stimulation (cTBS) targeting the right ATL 5 times a week for 2 weeks. Each stimulation session will be followed by 30-min of Speech and Language Therapy using the Semantic Feature Analysis protocol.

Experimental: Facilitatory rTMS

Participants will receive facilitatory intermittent Theta Burst Stimulation (iTBS) targeting the left ATL 5 times a week for 2 weeks. Each stimulation session will be followed by 30-min of Speech and Language Therapy using the Semantic Feature Analysis protocol.

Sham_comparator: Sham rTMS

Participants will receive sham stimulation targeting either the left or right ATL with allocation balanced across participants, 5 times a week for 2 weeks. Each stimulation session will be followed by 30-min of Speech and Language Therapy using the Semantic Feature Analysis protocol.

Related Therapeutic Areas

Stroke

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