Synovial Sarcoma
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Synovial Sarcoma Overview

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Learn About Synovial Sarcoma

What is the definition of Synovial Sarcoma?
Synovial sarcoma is a rare and aggressive soft tissue sarcoma. However, as the tumor grows larger, affected people may notice a lump or swelling. In some cases, the tumor can limit range of motion or cause numbness and/or pain if it presses on nearby nerves. Although Synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease. Cells in these tumors are usually characterized by the presence of a translocation involving chromosomes X and 18. This translocation is specific to Synovial sarcoma and is often used to diagnose the condition.
What are the alternative names for Synovial Sarcoma?
  • Synovial sarcoma
  • Synovial cell sarcoma
  • Synovialosarcoma
Who are the top Synovial Sarcoma Local Doctors?
Elite in Synovial Sarcoma
Dr. Melissa A. Burgess
Hematology Oncology
Elite in Synovial Sarcoma
Dr. Melissa A. Burgess
Hematology Oncology
Referral may be required

UPMC Hillman Cancer Center

5115 Centre Avenue, Hillman Cancer Center, 
Pittsburgh, PA 
412-623-4759
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Melissa Burgess, MD, is an assistant professor at the University of Pittsburgh School of Medicine and a medical oncologist. She specializes in the treatment of soft tissue and bone sarcomas and Merkel cell carcinoma. Dr. Burgess is rated as an Elite provider by MediFind in the treatment of Synovial Sarcoma. She is also highly rated in 42 other conditions, according to our data. Her clinical expertise encompasses Adult Soft Tissue Sarcoma, Liposarcoma, Merkel Cell Carcinoma, Chondrosarcoma, and Gamma Knife Radiosurgery. Dr. Burgess is board certified in American Board Of Internal Medicine. Dr. Burgess is currently accepting new patients.

Elite in Synovial Sarcoma
Dr. Sandra D'angelo
Oncology
Elite in Synovial Sarcoma
Dr. Sandra D'angelo
Oncology
Referral may be required

Rockefeller Outpatient Pavilion

160 E 53rd St, 
New York, NY 
646-583-3648
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Sandra D'angelo is an Oncologist practicing medicine in New York, New York. Dr. D'angelo is rated as an Elite provider by MediFind in the treatment of Synovial Sarcoma. She is also highly rated in 33 other conditions, according to our data. Her clinical expertise encompasses Synovial Sarcoma, Adult Soft Tissue Sarcoma, Liposarcoma, Merkel Cell Carcinoma, and Liver Embolization. Dr. D'angelo is currently accepting new patients.

 
 
 
 
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Elite in Synovial Sarcoma
Dr. Rashmi Chugh
Oncology | Hematology | Internal Medicine
Elite in Synovial Sarcoma
Dr. Rashmi Chugh
Oncology | Hematology | Internal Medicine
Referral may be required

Rogel Cancer Center

1500 E Medical Center Dr, Floor B1 Reception E, 
Ann Arbor, MI 
734-647-8902
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Rashmi Chugh is a Hematologist and an Oncologist practicing medicine in Ann Arbor, Michigan. Dr. Chugh is rated as an Elite provider by MediFind in the treatment of Synovial Sarcoma. She is also highly rated in 32 other conditions, according to our data. Her clinical expertise encompasses Adult Soft Tissue Sarcoma, Epithelioid Sarcoma, Desmoid Tumor, and Ewing Sarcoma.

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What are the latest Synovial Sarcoma Clinical Trials?
A Non-Randomized, Open-label Phase II Trial Testing the Activity of XL092 (Zanzalintinib) in Patients With Advanced Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma
A Non-Randomized, Open-label Phase II Trial Testing the Activity of XL092 (Zanzalintinib) in Patients With Advanced Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma
Enrollment Status: Recruiting
Publish Date: June 18, 2026
Intervention Type: Procedure, Drug
Study Phase: Phase 2

Summary: This phase II trial tests how well zanzalintinib (XL092) works in treating patients with leiomyosarcoma that has spread from where it first started to other places in the body (metastatic) or that cannot be removed by surgery (unresectable). Leiomyosarcomas are a type sarcoma that can occur in any location in the body, such as the uterus or in the abdomen. Current standard treatment for leiomyosar...

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A Pilot Trial of N-803 in Patients With Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy
A Pilot Trial of N-803 in Patients With Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy
Enrollment Status: Recruiting
Publish Date: June 15, 2026
Intervention Type: Procedure, Biological
Study Phase: Early Phase 1

Summary: This early phase I trial tests the safety and how well N-803 works in treating patients with synovial sarcoma (SS) or myxoid/round cell liposarcoma (MRCL) that is growing, spreading, or getting worse (progressive) after being treated with adoptive cellular therapy (ACT) using T-cell receptor therapy (T-CRT). Synovial sarcoma is a rare, slow-growing cancer that affects the soft tissues, like muscle...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center