Transient Familial HyperbilirubinemiaSymptoms, Doctors, Treatments, Advances & More
Learn About Transient Familial Hyperbilirubinemia
Transient familial hyperbilirubinemia is a metabolic condition that is passed down through families. Babies with this disorder are born with severe jaundice.
Lucey-Driscoll syndrome
Transient familial hyperbilirubinemia is an inherited condition. It occurs when the body does not properly break down (metabolize) a certain form of bilirubin. Bilirubin levels rapidly build up in the body. The high levels are poisonous to the brain and can cause death.
Your newborn may have:
- Yellow skin (jaundice)
- Yellow eyes (icterus)
- Lethargy
If untreated, seizures and neurologic problems (kernicterus) may develop.
Phototherapy with blue light is used to treat the high level of bilirubin. An exchange transfusion is sometimes necessary if the levels are extremely high.
Atrium Health Concierge Care Lake Norman
Christopher Messitt is a primary care provider, practicing in Family Medicine in Cornelius, North Carolina. Dr. Messitt is rated as a Distinguished provider by MediFind in the treatment of Transient Familial Hyperbilirubinemia. He is also highly rated in 5 other conditions, according to our data. His clinical expertise encompasses Transient Familial Hyperbilirubinemia, Thyroid Dysgenesis, Congenital Hypothyroidism, and Newborn Jaundice. Dr. Messitt is board certified in American Board Of Family Medicine. Dr. Messitt is currently accepting new patients.
Texas Health Family Care
Richard Townsend is a primary care provider, practicing in General Practice in Richardson, Texas. Dr. Townsend is rated as an Advanced provider by MediFind in the treatment of Transient Familial Hyperbilirubinemia. He is also highly rated in 26 other conditions, according to our data. His clinical expertise encompasses Vitamin D Deficiency, Gilbert Syndrome, High Cholesterol, and Nephrosclerosis.
Lucile Packard Children's Hospital Stanford
Vinod Bhutani is a Neonatologist practicing medicine in Palo Alto, California. Dr. Bhutani is rated as an Elite provider by MediFind in the treatment of Transient Familial Hyperbilirubinemia. He is also highly rated in 7 other conditions, according to our data. His clinical expertise encompasses Bilirubin Encephalopathy, Transient Familial Hyperbilirubinemia, Hemolytic Disease of the Newborn, and Jaundice.
Babies who are treated can have a good outcome. If the condition is not treated, severe complications develop. This disorder tends to improve with time.
Death or severe brain and nervous system (neurological) problems can occur if the condition is not treated.
This problem is most often found in the first few days after delivery. However, contact your health care provider if you notice your baby's skin turning yellow. There are other causes for jaundice in the newborn that are easily treated.
Genetic counseling can help families understand the condition, its risks of recurring, and how to care for the person.
Phototherapy can help prevent serious complications of this condition.
Summary: This is a prospective, open-label, randomized controlled trial conducted at Lattakia University Hospital (Tishreen University), aiming to evaluate the efficacy of Ursodeoxycholic Acid (UDCA) as an adjuvant to triple phototherapy in the management of indirect hyperbilirubinemia in neonates ≥34 weeks of gestation. Eligible neonates will be randomly assigned to one of two groups: Group A: continuous ...
Summary: Neonatal jaundice, or neonatal hyperbilirubinemia, is a common medical issue in the first two weeks of life, causing prolonged hospitalization and readmissions. It results from elevated total serum bilirubin (TSB) and is manifested as yellowish discoloration of the skin, sclera, and mucous membrane. Clinical jaundice appears in about 60% of term neonates and 80% of preterm infants within the first...
Published Date: July 28, 2025
Published By: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
National Institutes of Health. National Center for Advancing Translational Sciences. Genetic and Rare Diseases Information Center website. Transient familial neonatal hyperbilirubinemia. rarediseases.info.nih.gov/diseases/2791/transient-familial-neonatal-hyperbilirubinemia. Updated February 2026. Accessed March 4, 2026.
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