Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks. Randomized clinical trials (RCTs) have demonstrated the benefits of carotid endarterectomy (CEA) in reducing stroke risk in patients with severe symptomatic carotid stenosis. Carotid artery stenting (CAS) has been developed as an alternative to CEA, offering several potential advantages, such as avoiding local surgical complications. However, unlike CEA, CAS has not been compared to medical therapy in RCTs for symptomatic carotid stenosis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient age 18 years or over

• Hemispheric or retinal transient ischemic attack or a non-disabling stroke (or retinal infarct) within 15 days before enrolment

• Stenosis of 50% to 99% in the symptomatic carotid artery (NASCET method) for whom revascularisation is decided according to guidelines

Locations
Other Locations
France
Centre hospitalier Sainte-Anne
RECRUITING
Paris
Contact Information
Primary
David Calvet, Professor
d.calvet@ghu-paris.fr
+33145658634
Backup
DRCI DRCI
info-recherche@ghu-paris.fr
Time Frame
Start Date: 2025-07-16
Estimated Completion Date: 2028-03-16
Participants
Target number of participants: 600
Treatments
Active_comparator: surgical arm
carotid endarterectomy
Active_comparator: Stenting arm
Carotid artery stenting
Sponsors
Leads: Centre Hospitalier St Anne
Collaborators: Direction Générale de l'Offre de Soins

This content was sourced from clinicaltrials.gov