Effect of Intravenous Infusion of Esketamine Combined Pulsed Radiofrequency on Acute/Subacute Zoster-associated Trigeminal Neuralgia
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
To assess the 1-month effects and safety of esketamine combined PRF and standardized treatment to relieve pain in patients with acute/subacute zoster-related trigeminal neuralgia(ZRTN).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age \>18 years;
• History of HZ within the last three months;
• Lesions located in the trigeminal nerve or its branches innervated regions；
• Numeric Rating Scale (NRS) pain score≥4 (NRS, 0 = no pain, 10= worst possible pain) with pharmacotherapy;
• Planned to perform CT-guided PRF treatment of the Gasserian ganglion .
Locations
Other Locations
China
Beijing Tiantan Hospital
RECRUITING
Beijing
Contact Information
Primary
Fang Luo, M.D.
13611326978@163.com
+86 13611326978
Time Frame
Start Date: 2025-04-01
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 174
Treatments
Experimental: Esketamine group
Besides PRF plus standardized treatment, patients will also receive intravenous infusion of Esketamine ;
Active_comparator: control group
Patients will only receive PRF plus standardized treatment
Related Therapeutic Areas
Sponsors
Collaborators: Beijing Xiaotangshan Hospital, Hengshui People's Hospital, The First Hospital of Fangshan District,Beijing, Beijing Ditan Hospital
Leads: Beijing Tiantan Hospital