Inflammatory Challenge and Fear Extinction: A Model to Enhance Understanding of Posttraumatic Stress Disorder

Status: Recruiting
Location: See location...
Intervention Type: Biological, Other
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 45
Healthy Volunteers: t
View:

⁃ All Subjects:

• Aged 25-45 years old

• Trauma Exposed

• Current PTSD/No history of PTSD

Locations
United States
California
San Francisco VA Health Care System
RECRUITING
San Francisco
Contact Information
Primary
Aoife O'Donovan, PhD
aoife.odonovan@ucsf.edu
415-221-4810
Backup
Michael Srouji, BA
415-221-4810
Time Frame
Start Date: 2025-03-28
Estimated Completion Date: 2028-11
Participants
Target number of participants: 288
Treatments
Experimental: Polysaccharide typhoid vaccine
Participants in this condition will receive an injection of 0.5ml Salmonella typhi capsular polysaccharide vaccine (Sanofi Pasteur, SA), which contains 25μg of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7±0.3), 4.150mg of sodium chloride, 0.065mg of disodium phosphate, 0.023mg of monosodium phosphate and 0.5ml of sterile water for injection.
Placebo_comparator: Saline Placebo Arm
Participants in this condition will receive and injection of 0.5ml of saline.
Sponsors
Collaborators: San Francisco Veterans Affairs Medical Center, National Institute of Mental Health (NIMH), Northern California Institute of Research and Education
Leads: University of California, San Francisco

This content was sourced from clinicaltrials.gov