Fexofenadine as Adjunct to Standard Rheumatoid Therapy in Patients With Active Rheumatoid
Rheumatoid arthritis (RA) is an inflammatory autoimmune polyarthritis affecting ∼1% of the world population, resulting in the loss of joint function and progressive structural damage in affected joints. Fexofenadine has been widely used to treat various allergic diseases, like allergic rhinitis, conjunctivitis and chronic idiopathic urticaria. the molecular mechanisms underlying fexofenadine mediated inhibition of TNF-α signalling
• Moderate to severe RA (disease activity score-28 joints: DAS-28 \> 3.2) were recruited.
• Age between 18 - 60 years having active disease according to the diagnosis of an experienced rheumatologist, being under treatment with disease-modifying anti-rheumatic drugs (DMARDs), not receiving cytokine inhibitors
• Signing informed consent and willingness of the participant to accept randomization to any assigned treatment arm.