Randomized Controlled Trial Evaluating the Effectiveness of a Breathing Control Technique on Long COVID Symptoms at the Reunion University Hospital

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Despite the controversy, on October 6, 2021, the World Health Organization (WHO) recognized Long Coronavirus disease (COVID) by officially defining it: symptoms appeared 3 months after the onset of the primary infection by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), persisting for at least 2 months and which cannot be explained by any other condition . Long COVID can affects any type of patient and has polymorphic and fluctuating symptoms over time. The Reunion Island is a French overseas department located in the Indian Ocean accounting more than 860,000 inhabitants. It has recorded since March 11, 2020, nearly 491,825 cases of COVID-19 and 961 deaths of hospitalized patients. Reunion's population is multi-ethnic and younger than the metropolitan France's one. It also has a higher prevalence of obesity and type 2 diabetes, two serious form factors of COVID-19. This specific context makes this island a particular study site for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Long COVID. In addition, some studies have confirmed the involvement of the autonomic nervous system (ANS) in the symptomatology of Long COVID and demonstrated that patients with a Long COVID present a dysfunction of their ANS which is objectified by a reduced Heart Rate Variability (HRV). The regulation of heart rate by the ANS is strongly favored by respiration. A regular slow and deep breathing training helps to adjust the baroreflex, which connect heart rate, breathing and blood pressure. The result of this training is an induced state called cardiac coherence (CC). The investigator therefore hypothesize that respiratory training to CC could re-educate the ANS and durably improve the symptomatology of patients with Long COVID.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients over the age of 18,

• living in Reunion and

• having a diagnosis of Long COVID according to the World Health Organization (WHO) definition will be included in this study.

• These patients must attest to their primary infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and present a negative antigen test at the time of inclusion.

Locations
Other Locations
France
CHU de la Réunion
RECRUITING
Saint-denis
CHU de la Réunion
NOT_YET_RECRUITING
Saint-pierre
Contact Information
Primary
Léa BRUNEAU
lea.bruneau@chu-reunion.fr
02 62 90 68 83
Time Frame
Start Date: 2025-05-05
Estimated Completion Date: 2027-04
Participants
Target number of participants: 200
Treatments
Experimental: Complementary respiratory training to cardiac coherence (CC)
The intervention group will benefit from a complementary respiratory training to CC during 6 months in addition to the usual care procedure.
No_intervention: Usual care procedure in the event of Long COVID
The control group will follow a usual care procedure in the event of Long COVID
Sponsors
Leads: Centre Hospitalier Universitaire de la Réunion

This content was sourced from clinicaltrials.gov

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