Type 2 Diabetes (T2D) Clinical Trials

Find Type 2 Diabetes (T2D) Clinical Trials Near You

Targeted Precision Nutrition Strategy To Prevent Chronic Metabolic Diseases

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Nutrition is very important to keep blood sugar levels balanced. If blood sugar levels are too high, it can lead to diseases such as cardiovascular disease and type 2 diabetes (T2DM). Therefore, adjusting what one eats, also called a diet or nutritional intervention, can help prevent these diseases. However, not everyone responds the same to a diet. In about 30% of people, a diet does not work as hoped. This can be due to various reasons, such as a person's metabolism, genetic predisposition, the composition of the food one eats, or the bacteria in the intestines. Everyday things like sleep, stress, and movement also play a role. The investigators used a computer model to classify people with overweight and obesity into groups based on these factors. The investigators call such a group a 'Metabolic Phenotype', or in short 'Metabotype'. Based on the Metabotype, a personalised diet was developed (personalised nutrition intervention) that may better suit each person's unique situation. The investigators hypothesize that a precision nutrition intervention, tailored to Metabotypes identified through unsupervised clustering (using the aforementioned computer model) of predefined, accurate features related to cardiometabolic health-specifically, tissue-specific glucose and lipid metabolism and detailed body composition-will enhance blood glucose homeostasis, reduce cardiometabolic risk, and improve adherence to the intervention and mental well-being, compared to population-based dietary guidelines. The present project will contribute to targeted and efficient precision-based dietary strategies for individuals at increased risk of T2DM.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 75
Healthy Volunteers: t
View:

• Men and women with a BMI ≥25 to \<40 kg/m2

• Classification possible to one of the investigational metabolic phenotypes according to the classification algorithm.

• Weight stability for at least 3 months (+/- 3 kg)

Locations
Other Locations
Netherlands
Maastricht University Medical Center, Department of Human Biology, NUTRIM Institute of Nutrition and Translational Research in Metabolism
RECRUITING
Maastricht
Wageningen University and Research, Division of Human Nutrition
RECRUITING
Wageningen
Contact Information
Primary
Ellen E Blaak, Prof. Dr. Ir.
e.blaak@maastrichtuniversity.nl
+31433881503
Backup
Art Muijsenberg, MSc
art.muijsenberg@maastrichtuniversity.nl
+31433882862
Time Frame
Start Date: 2025-04-23
Estimated Completion Date: 2027-04
Participants
Target number of participants: 240
Treatments
Experimental: Precision Nutrition Group (PN)
For a total duration of 12 months, participants in the Precision Nutrition (PN) Group will follow a diet tailored to their Metabotype, which is hypothesised to be optimal for them.
Experimental: Control Group (CN)
For a total duration of 12 months, participants in the Control Group (CN) will be randomly assigned one of the diets optimised for a different Metabotype of the same sex, which is hypothesised to be suboptimal for them.
Related Therapeutic Areas
Sponsors
Collaborators: TKI Agri & Food, BARILLA G. e R. Fratelli S.p.A., Parma, Italy, Wageningen University and Research, Health Holland, Nestle Health Science, Beneo GmbH
Leads: Maastricht University Medical Center

This content was sourced from clinicaltrials.gov