Who Will Benefit From Bariatric Surgery for Diabetes? Using Fat Distribution Measurement, Gut Hormone Profiles and Genetic Data to Predict Diabetes Remission
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
A study investigating the influence of fat distribution, genetic susceptibility markers for type 2 diabetes (T2DM) and fat distribution, epigenetic and transcriptomic changes and gut hormone responses to a mixed meal on diabetes remission following bariatric surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:
• Males and females planning to undergo RYGB
• 18-80 years
• Type 2 diabetes mellitus or prediabetes
• Stable weight for at least 3 months
• Obese (BMI ≥30kg/m2)
• Eligible for surgery on the National Health Service (NHS) under The National Institute for Health and Care Excellence (NICE) 2014 criteria
• Aged 18-80 years
• Male or female
• Body mass index 19 - 25 kg/m2
• Stable weight for at least three months
Locations
Other Locations
United Kingdom
Imperial College Healthcare NHS Trust
RECRUITING
London
Contact Information
Primary
Julia S Kenkre, MB BChir
imperial.bariatricstudy@nhs.net
+44208383242
Time Frame
Start Date: 2018-10-01
Estimated Completion Date: 2028-10-05
Participants
Target number of participants: 210
Treatments
Surgical cohort
Patients with type 2 diabetes undergoing Roux-en-Y gastric bypass surgery
Control
Healthy volunteers with normal body mass index
Related Therapeutic Areas
Sponsors
Leads: Imperial College London
Collaborators: National Institute for Health Research, United Kingdom