Benefit of Gonadotropin-releasing Hormone (GnRH) Agonist Before Frozen Embryo Transfer in Patients With Endometriosis and / or Adenomyosis: Randomized Prospective Study

Who is this study for? Patients with endometriosis and/or adenomyosis
What treatments are being studied? GnRH agonist
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY

Women suffering from endometriosis and/or adenomyosis may also suffer from infertility. GnRH agonist injection could improve implantation and therefore increase the pregnancy rate in these patients. This study was designed to evaluate effects of the additional of GnRH agonist (single or 2 doses) to the routine oestrogens and progestins use as support before Frozen Embryon Transfer as compared to oestrogens and progestins only.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 36
Healthy Volunteers: f
View:

• Women aged 18 to 36 years (women ≥18 years to \<36 years) with endometriosis and / or adenomyosis

• Having benefited from In vitro fertilisation /intracytoplasmic micro-injection with freeze all and for whom the frozen embryon transfer of a blastocyst is planned

• A normal uterine cavity

• An MRI showing endometriosis and / or adenomyosis during the inclusion visit

• Having signed a consent form

• Being affiliated to a Health Insurance Plan.

Locations
Other Locations
France
Hopital Foch
RECRUITING
Suresnes
Contact Information
Primary
Elisabeth Hulier-Ammar, Dr
e.hulier-ammar@hopital-foch.com
0033146251175
Time Frame
Start Date: 2021-03-18
Estimated Completion Date: 2026-06-18
Participants
Target number of participants: 180
Treatments
No_intervention: Frozen embryo transfer with Hormonal Replacement Therapy (HRT)
Patient will received usual Hormonal Replacement Therapy for a Frozen embryo transfer composed of estrogens and progestins.
Experimental: Frozen embryo transfer with HRT and GnRH agonist
Patient will received 1 or 2 injection of GnRH agonist priori to usual Hormonal Replacement Therapy for a Frozen embryo transfer composed of estrogens and progestins.
Related Therapeutic Areas
Sponsors
Leads: Hopital Foch

This content was sourced from clinicaltrials.gov