68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT): a Randomized Cross-over Trial
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
To validate the accuracy of 68Ga-Pentixafor PET/CT and adrenal venous sampling (AVS) in subtype diagnosis of PA/ACS patients with adrenal nodules, based on biochemical and clinical remission outcomes, and to determine whether the diagnostic accuracy of 68Ga-Pentixafor PET/CT is non-inferior to AVS.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Getting the written informed consent;
• PA conccurent with autonomous cortisol secretion;
• Patients with hypertension aged 18-70 years;
• CT or MRI scan of the adrenal glands with adenoma. Exclusion criteria
Locations
Other Locations
China
The First Affilated Hospital of Chongqing Medical University
RECRUITING
Chongqing
Contact Information
Primary
Qifu Li
liqifu@yeah.net
+86 023-89011552
Time Frame
Start Date: 2024-08-01
Estimated Completion Date: 2029-12-31
Participants
Target number of participants: 178
Treatments
Experimental: 68Ga-Pentixafor PET/CT group
Patients in the 68Ga-Pentixafor PET/CTgroup will first undergo 68Ga-Pentixafor PET/CT, followed by adrenal venous sampling (AVS). The subsequent treatment will be guided based on the diagnostic results.
Experimental: AVS group
Patients in the adrenal venous sampling (AVS) will first undergo adrenal venous sampling (AVS) , followed by 68Ga-Pentixafor PET/CT. The subsequent treatment will be guided based on the diagnostic results.
Related Therapeutic Areas
Sponsors
Collaborators: First Affiliated Hospital of Kunming Medical University, The Affiliated Hospital Of Southwest Medical University, Changzhi Medical College
Leads: Qifu Li