Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume, improves vascular function of the conduit vessels, and enhances insulin's metabolic action in humans with Metabolic Syndrome. Subjects will be randomized to one of the 4 groups: control, exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the baseline and then after 24 weeks of intervention.
• Male or female ≥21 and ≤60 years old.
• Body mass index \>25 and ≤35 kg/m2 and is weight stable (\<5 kg weight change in the past 6 months). BMI is limited to ≤35 kg/m2 for easier vascular access and cardiac imaging.
• Meet 3 of 5 National Cholesterol Education Program Adult Treatment Panel III Metabolic Syndrome criteria:
‣ Increased waist circumference (≥102 cm in men; ≥88 cm in women)
⁃ Elevated triglycerides (≥150 mg/dl)
⁃ Reduced HDL-cholesterol (\<40mg/dl in men, \<50 mg/dl in women)
⁃ High blood pressure (≥130 mmHg systolic or ≥85mmHg diastolic)
⁃ Elevated fasting glucose (≥100 mg/dl)
⁃ Subject may participate if on the following drugs, provided the drug doses have been stable for at least 3 months.
⁃ Ace inhibitor
⁃ ARB
⁃ HMG CoA reductase inhibitor
⁃ Beta blocker
⁃ Calcium channel blockers
⁃ Alpha-adrenergic antagonist
⁃ Statin