Randomized Study Evaluating the Cost Impact and Effectiveness of Systematic Liver Fast-MRI Surveillance for Early-stage Hepatocellular Carcinoma in High-risk Patients Included in Ultrasound Surveillance Programs
Objective: The main objective is to assess the cost / QALY and / patient detected with an early HCC BCLC 0 (single tumor \<2cm) by semi-annual monitoring by liver US and Fast-MRI, compared to conventional semi-annual monitoring by liver US alone in patients with cirrhosis and an anticipated HCC incidence\>3%.
Conclusion: If positive, this trial could modify international practice guidelines and set MRI as the optimal tool for early HCC detection in high-risk patients.
• Age ≥ 18 years
• Patient enrolled in a screening program for at least 6 months in a tertiary hepatology center
• Cirrhosis histologically proven or unequivocally suggested by non-invasive tests
• Absence of HCC on imaging less than 3 months o
• Liver parenchyma explorable by ultrasound
• Child-Pugh A or B
• Cirrhosis of non-viral or viral B/C cause controlled/healed
• With an estimated annual risk of HCC\>3%
• Written informed consent
• Affiliation to a social security system