Dinner Time for Obesity and Prediabetes

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by which late eating harms metabolism is not fully understood but may be related to mis-timing of food intake in relation to the body's endogenous circadian rhythm. Conversely, harmonization of eating timing with endogenous circadian rhythm may optimize metabolic health. In this study the investigators will use gold-standard methods of characterizing circadian rhythm in humans to examine the metabolic impacts food timing relative to endogenous circadian rhythm.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: t
View:

• For the Normal-Weight Healthy (NWH) cohort: Healthy male and female adults, age 18-50, with BMI 18-24.9 kg/m2 inclusively

• For the Obesity-Prediabetes (OPD) cohort: Male and female adults, age 18-50, with BMI ≥30 kg/m2 and prediabetes

• All participants must be able to understand study procedures, to comply with the procedures for the entire length of the study and be fully mobile.

Locations
United States
Maryland
Johns Hopkins Bayview Medical Center
RECRUITING
Baltimore
National Institutes of Health Clinical Center
NOT_YET_RECRUITING
Bethesda
Contact Information
Primary
Athena Mavronis
amavron1@jhmi.edu
(410) 550-4588
Backup
Mariah Potocki
mchaney7@jhmi.edu
410-550-2233
Time Frame
Start Date: 2023-07-05
Estimated Completion Date: 2028-03-31
Participants
Target number of participants: 32
Treatments
Experimental: Early Dinner First
Participants will be served dinner and a stable isotope of oral \[2H31\] palmitate to measure fat oxidation, at an early dinner time (before DLMO). This arm will then cross-over to Late Dinner as the second metabolic visit.
Experimental: Late Dinner First
Participants will be served dinner and a stable isotope of oral \[2H31\] palmitate to measure fat oxidation, at a late dinner time (after DLMO). This arm will then cross-over to Early Dinner as the second metabolic visit.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leads: Johns Hopkins University

This content was sourced from clinicaltrials.gov