Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous Hypercorticism

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The main hypothesis of the HEPACORT study is that upon diagnosis of endogenous Cushing's syndrome, significant liver fibrosis may be present, particularly in the most severe forms of Cushing's syndrome. the HEPACORT study is the first exploratory study to assess the severity of liver fibrosis in patients with Cushing's syndrome or suspected of presenting by Magnetic Resonance Elastography (MRE).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• age ≥ 18 years old;

• Person affiliated to a social security scheme or beneficiary of such a scheme;

• Person having received complete information on the organization of the research and having signed informed consent;

• Person having carried out a preliminary clinical examination adapted to the research.

• Patients with Cushing's syndrome (for the Cushing's Syndrome group)

• Patients with possible Cushing's syndrome (for the suspected Cushing's Syndrome group) defined as response to the dexamethasone supression test with 1 mg of Dexamethasone, with a plasma cortisol assay at 8 am between 18 and 50 µg/L carried out in the 3 months preceding ;

• Patients with metabolic syndrome (for the metabolic syndrome group)

Locations
Other Locations
France
CHRU Nancy
RECRUITING
Nancy
Contact Information
Primary
Nicolas SCHEYER, MD
n.scheyer@chru-nancy.fr
+33383154302
Backup
Guillaume DROUOT, PhD
g.drouot@chru-nancy.fr
+33383157666
Time Frame
Start Date: 2023-10-24
Estimated Completion Date: 2026-08-31
Participants
Target number of participants: 21
Treatments
Experimental: Cushing's Syndrome
Patients with proven autonomic cortisol secretion (Cushing's Syndrome)
Experimental: Suspected Cushing's Syndrome
Patients with possible autonomic cortisol secretion (Suspected Cushing's Syndrome)
Active_comparator: Metabolic Syndrome
Patients with metabolic syndrome
Sponsors
Leads: Central Hospital, Nancy, France

This content was sourced from clinicaltrials.gov