Standardized Meals With Different Macronutrient Ratios on the Postprandial Metabolome and Metabolic Flexibility

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Metabolic flexibility is a process in which the body can switch energy substrates in different physiological states. This flexibility plays an important role in an individual's health because losing it increases the risk of obesity, metabolic syndrome, insulin resistance, and type 2 diabetes. Considering that humans spend most of their awakening hours in a postprandial (PP) state, an organism's metabolic flexibility (MF) to respond to a standardized meal's consumption would provide information on the individual's metabolic health. The PP response to glucose following an oral glucose tolerance test or consumption of a high-carbohydrate meal is well described; however, few studies assess the FM and PP metabolome using mixed meals with different macronutrients. The investigators address how metabolic flexibility and metabolome change after consuming standardized meals with different macronutrient ratios. Data collection includes clinical and diet information, indirect calorimetry, and capillary blood sampling during fasting and after consumption of standardized meals. Samples are collected weekly for one month. The data will determine the metabolic flexibility and metabolome after consuming standardized meals with different macronutrient ratios.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 30
Healthy Volunteers: t
View:

• be over 18 years of age and under 30 years of age;

• without active drug addictions: smoking, alcoholism, and/or drug addiction;

• in female subjects: regular menstrual cycles;

• give written consent for their inclusion in the study.

Locations
Other Locations
Mexico
Berenice Palacios-Gonzalez
RECRUITING
Mexico City
Contact Information
Primary
Berenice Palacios-Gonzalez, PhD
bpalacios@inmegen.gob.mx
5553501900
Backup
Noemi Meraz-Cruz, PhD
nmeraz@inmegen.gob.mx
5553501900
Time Frame
Start Date: 2024-01-08
Estimated Completion Date: 2026-12-18
Participants
Target number of participants: 300
Treatments
Experimental: High carbohydrate challenge
High carbohydrate challenge should be consumed within 15 minutes. After 5 minutes of rest, indirect calorimetry will be postprandially, lasting 30 minutes.~Capillary blood shall be obtained at the following times: 15-30-45-60-90 and 120 min after ingestion of food.
Experimental: High lipid challenge
High lipid challenge should be consumed within 15 minutes. After 5 minutes of rest, indirect calorimetry will be postprandially, lasting 30 minutes. Capillary blood shall be obtained at the following times: 15-30-45-60-90 and 120 min after ingestion of food.
Experimental: High protein challenge
High protein challenge should be consumed within 15 minutes. After 5 minutes of rest, indirect calorimetry will be postprandially, lasting 30 minutes. Capillary blood shall be obtained at the following times: 15-30-45-60-90 and 120 min after ingestion of food.
Sponsors
Leads: Instituto Nacional de Medicina Genomica
Collaborators: Universidad Nacional Autonoma de Mexico

This content was sourced from clinicaltrials.gov