The Effectiveness of Intermittent Fasting, Caloric Restriction and Physical Activity Intervention On Metabolic Syndrome Biomarkers Among Adults With Metabolic Syndrome at Hospitals in Riyadh, Saudi Arabia

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Metabolic syndrome (MetS) is a global health issue defined by a cluster of risk factors-abdominal obesity, elevated blood pressure, high fasting blood sugar, high triglycerides, and low HDL cholesterol-that together significantly increase the risk of cardiovascular disease, type 2 diabetes, and overall mortality. Globally, about 20-25% of adults are affected, but prevalence varies by region and population; in Saudi Arabia, studies report rates ranging from 28.3% to 56.4%, with higher rates observed in northern and central regions and among men. Major contributors to MetS in Saudi Arabia include obesity, sedentary lifestyle, smoking, and poor dietary habits, such as low fruit consumption. Effective management strategies focus on weight loss through caloric restriction, intermittent fasting, and increased physical activity, all of which have demonstrated improvements in metabolic markers like insulin sensitivity, blood pressure, and lipid profiles. Despite international evidence supporting these interventions, no randomized controlled trials have yet evaluated the combined effects of these approaches on MetS biomarkers in Saudi adults, underscoring the need for targeted research and public health initiatives to address the high and regionally variable burden of MetS in the country.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• The inclusion criteria will be adult aged 18 years and above who have three or more of the following five risk factors (Kunduraci \& Ozbek, 2020):

‣ Abdominal obesity.

⁃ Elevated triglycerides.

⁃ Low HDL cholesterol.

⁃ Elevated blood pressure.

⁃ Elevated fasting blood glucose.

Locations
Other Locations
Malaysia
Associate Professor Dr. Hazizi Abu Saad
RECRUITING
Serdang
Contact Information
Primary
Lamia Salem Almazid, Master
drlamiasalem2024@gmail.com
+601161519002
Backup
Hazizi Abu Saad, PhD
hazizi@upm.edu.my
+60397692434
Time Frame
Start Date: 2025-04-01
Estimated Completion Date: 2027-12-30
Participants
Target number of participants: 140
Treatments
Other: Modified Intermittent Fasting
Intervention program of modified Intermittent fasting (Intermittent fasting, caloric restriction and physical activity)
No_intervention: Control group: No Intervention
A control group receiving standard care provided by hospital
Sponsors
Leads: Universiti Putra Malaysia

This content was sourced from clinicaltrials.gov