A Longitudinal Study of Orbital and Cranial Vessel Wall MRI in Giant Cell Arteritis by the Vascular MRI Evaluation in Giant Cell Arteritis (VEGA) Collaborative
Status: Recruiting
Location: See all (4) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes. The target population includes patient with suspected giant cell arteritis (GCA; temporal arteritis).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Healthy Volunteers: t
View:
• Age 50 years or older
• First presentation of suspected GCA
• New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA
• Elevated CRP greater than 1.0 mg/dl
• Plan to undergo temporal artery biopsy or ultrasound for diagnosis
Locations
United States
Minnesota
Mayo Building and Gonda Building
RECRUITING
Rochester
Pennsylvania
3400 Civic Center Blvd
RECRUITING
Philadelphia
Other Locations
Canada
St. Joseph's Healthcare Hamilton
NOT_YET_RECRUITING
Hamilton
Germany
University Hospital Wuerzburg
NOT_YET_RECRUITING
Würzburg
Contact Information
Primary
Brenda Hernandez-Romero, B.S
Brenda_Hernandez-Romero@pennmedicine.upenn.edu
917-548-2067
Time Frame
Start Date: 2020-07-29
Estimated Completion Date: 2033-07
Participants
Target number of participants: 400
Treatments
Ocular GCA
GCA with clinical diagnosis of ischemic optic neuropathy or other ocular condition
Non-Ocular GCA
GCA without ocular manifestations
Non-GCA
Initially suspected to have GCA but final clinical diagnosis not GCA
Related Therapeutic Areas
Sponsors
Leads: University of Pennsylvania
Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)