CanROC Epinephrine Dose: Optimal Versus Standard Evaluation Trial (CanROC EpiDOSE Trial)
Who is this study for? Patients with Sudden Cardiac Arrest, Ventricular Fibrillation
What treatments are being studied? Epinephrine
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Out-of-hospital cardiac arrest treated by paramedics
• Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or witnessed by EMS (paramedic or fire)
• Established intravenous vascular access
Locations
Other Locations
Canada
Halton Region Paramedic Services
RECRUITING
Halton
Ottawa Paramedic Services
RECRUITING
Ottawa
British Columbia Emergency Health Services (BCEHS)
RECRUITING
Victoria
Contact Information
Primary
Theresa Aves, MSc
theresa.aves@unityhealth.to
416-864-6060
Time Frame
Start Date: 2023-05-24
Estimated Completion Date: 2028-06
Participants
Target number of participants: 3790
Treatments
Active_comparator: Low Dose Epinephrine
Epinephrine up to 2mg total
Active_comparator: Standard Dose Epinephrine
Epinephrine up to 6mg total
Related Therapeutic Areas
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR), Pfizer
Leads: Unity Health Toronto