What is the definition of VEXAS Syndrome?

VEXAS syndrome is a severe inflammatory syndrome caused by a genetic mutation in bone marrow that only affects males.

What are the symptoms for VEXAS Syndrome?

Symptoms of VEXAS syndrome usually occur between 45 and 80 years of age and may include recurrent fevers, inflammation of the blood vessels, fluid and infections in the lungs, skin and eye inflammation, deep vein clots, joint pain, infections of the cartilage of the ear and nose, anemia, and sensorineural hearing loss.

What are the current treatments for VEXAS Syndrome?

There is currently no standard treatment for VEXAS syndrome. However, glucocorticoids have provided some symptom relief. Researchers are currently investigating bone marrow transplants and gene editing as possible treatments for VEXAS syndrome.

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