VEXAS Syndrome Overview

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Learn About VEXAS Syndrome

What is the definition of VEXAS Syndrome?
VEXAS syndrome is a severe inflammatory syndrome caused by a genetic mutation in bone marrow.
What are the symptoms of VEXAS Syndrome?
Symptoms of VEXAS syndrome usually occur between 45 and 80 years of age and may include recurrent fevers, inflammation of the blood vessels, fluid and infections in the lungs, skin and eye inflammation, deep vein clots, joint pain, infections of the cartilage of the ear and nose, anemia, and sensorineural hearing loss.
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What are the current treatments for VEXAS Syndrome?
There is currently no standard treatment for VEXAS syndrome. However, glucocorticoids have provided some symptom relief. Researchers are currently investigating bone marrow transplants and gene editing as possible treatments for VEXAS syndrome.
Who are the top VEXAS Syndrome Local Doctors?
Elite in VEXAS Syndrome
Mael Heiblig
Elite in VEXAS Syndrome
Mael Heiblig
Pierre-la-treiche, FR 

Mael Heiblig practices in Pierre-la-treiche, France. Mr. Heiblig is rated as an Elite expert by MediFind in the treatment of VEXAS Syndrome. His top areas of expertise are VEXAS Syndrome, Acute Myeloid Leukemia (AML), Leukemia, Myelodysplastic Syndrome (MDS), and Bone Marrow Transplant.

Elite in VEXAS Syndrome
Arsene M. Mekinian
Elite in VEXAS Syndrome
Arsene M. Mekinian
Paris, FR 

Arsene Mekinian practices in Paris, France. Mr. Mekinian is rated as an Elite expert by MediFind in the treatment of VEXAS Syndrome. His top areas of expertise are VEXAS Syndrome, Takayasu Arteritis, Vasculitis, Antiphospholipid Syndrome, and Intrauterine Device Insertion.

 
 
 
 
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Elite in VEXAS Syndrome
Vincent Jachiet
Elite in VEXAS Syndrome
Vincent Jachiet
Paris, FR 

Vincent Jachiet practices in Paris, France. Mr. Jachiet is rated as an Elite expert by MediFind in the treatment of VEXAS Syndrome. His top areas of expertise are VEXAS Syndrome, Chronic Myelomonocytic Leukemia (CMML), Myelodysplastic Syndrome (MDS), and Type B Insulin Resistance Syndrome.

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What are the latest VEXAS Syndrome Clinical Trials?
PAXIS: A Randomized, Double-blind, Placebo-controlled Dose-finding Phase 2 Study (Part 1) Followed by an Open-label Period (Part 2) to Assess the Efficacy and Safety of Pacritinib in Patients With VEXAS Syndrome
PAXIS: A Randomized, Double-blind, Placebo-controlled Dose-finding Phase 2 Study (Part 1) Followed by an Open-label Period (Part 2) to Assess the Efficacy and Safety of Pacritinib in Patients With VEXAS Syndrome
Enrollment Status: Recruiting
Publish Date: October 07, 2025
Intervention Type: Drug
Study Phase: Phase 2

Summary: This study is to assess the effectiveness and safety of pacritinib in patients with VEXAS (i.e., Vacuoles in myeloid progenitors, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory manifestations, and somatic) syndrome. 78 patients will be enrolled, randomized to either pacritinib dose A, pacritinib dose B + placebo, or placebo. Randomization will be stratified by prescribed GC dose on the...

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Multicenter, Interdisciplinary National VEXAS Registry With Accompanying Biomaterial Collection
Multicenter, Interdisciplinary National VEXAS Registry With Accompanying Biomaterial Collection
Enrollment Status: Recruiting
Publish Date: September 19, 2025

Summary: The aim is rapid collection of real-life data on the epidemiology, treatment and disease course in patients with VEXAS syndrome during routine clinical practice and collect biomaterials to evaluate genotype-phenotype associations, determine optimal treatment schedule, identify diagnostic features and biomarkers

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