Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy: A Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to compare dexmedetomidine and lidocaine infusions as adjuvants to general anesthesia for chronic pain management after mastectomy.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Age from 18 to 75 years.
• American Society of Anesthesiologists (ASA) physical status II.
• Scheduled for mastectomy with axillary dissection (either modified radical mastectomy with or without latissimus dorsi flap or conservative breast surgery) due to breast cancer.
Locations
Other Locations
Egypt
Cairo University
RECRUITING
Cairo
Contact Information
Primary
Mohamed E Abdel Fattah, MD
mohamed-elsaid@cu.edu.eg
00201284475792
Time Frame
Start Date: 2025-04-05
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 90
Treatments
Experimental: Dexmedetomidine group
Patients will receive 1 μg/kg of intravenous dexmedetomidine over 10 min followed by an intravenous infusion of 0.5 μg/kg/h.
Experimental: Lidocaine group
Patients will receive a bolus of intravenous lidocaine 1.5mg/kg over 10 min followed by a continuous infusion of lidocaine 1.5mg/kg/h.
Placebo_comparator: Control group
Patients will receive intravenous isotonic saline 0.9% in the same volume and manner as the study drugs.
Related Therapeutic Areas
Sponsors
Leads: Cairo University