Gynecological and Fertility Impact of Allogeneic Hematopoietic Stem Cell Transplantation for Acute Leukemia Diagnosed in Adulthood (GYNEGRAFT)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Gynecological impact and infertility are major issues for women after allogeneic hematopoietic stem cell transplantation. The aim of the present study is to investigate the prevalence of gynecological complications after allogeneic hematopoietic stem cell transplantation for acute leukemia in adulthood. By conducting a single-center retrospective descriptive analysis, the prevalence, follow-up and treatment of gynecological complications -including premature ovarian failure, vulvovaginal graft-versus-host-disease, cervical pathology- will be analysed

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: f
View:

• Women diagnosed with acute leukemia, who underwent allogeneic hematopoietic stem cell transplantation in adulthood (\>18 years),

• Aged 20 to 45 at the time of evaluation,

• At least 2 years post-transplant.

• French-speaking patients, without comprehension disorders, and literate,

• No objection to participation.

Locations
Other Locations
France
CHU Bordeaux
RECRUITING
Bordeaux
Contact Information
Primary
Valerie Bernard, MD, PhD
valerie.bernard@chu-bordeaux.fr
+33557820940
Time Frame
Start Date: 2025-09-19
Estimated Completion Date: 2026-07
Participants
Target number of participants: 80
Treatments
Experimental: Questionnaire
A standardized questionnaire was specifically developed for the study to explore:~* Women's socio-demographic data~* Data about their hematological disease (type of leukemia, conditioning protocol, relapses, graft-versus-host disease etc.)~* Information received by patients prior to transplantation concerning gynecological complications~* Symptoms, screening, diagnosis and treatment of the main gynecological complications~* Patients fertility (spontaneous or after assisted reproductive treatments)
Related Therapeutic Areas
Leukemia
Infertility
Graft Versus Host Disease (GvHD)
Bone Marrow Transplant
Sponsors
Leads: University Hospital, Bordeaux

This content was sourced from clinicaltrials.gov

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