ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

We propose to study approach/avoidance behavior as measured by the Approach Avoidance task in 20 epilepsy patients undergoing implementation of depth electrodes for seizure monitoring in the Epilepsy Monitoring Unit at MGH. We will also study the effects of VC/VS electrical stimulation on approach-avoidance conflict in 20 adult patients who have undergone DBS implantation for severe MDD and/or OCD. There are 100-200 patients in the world with DBS electrodes in the VC/VS, and our research team cares for more than any other institution. Both participant groups will be assessed with respect to reward-aversion decision conflict using the task. The task will be performed with concurrent EEG recordings in DBS patients, and with continuous recording through our invasive neurophysiology rig in EMU subjects.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

⁃ • Deep brain stimulator implantation performed at least three months prior to study

• Right-handed (as determined by the Handedness Inventory; Oldfield,1971)

• Normal or corrected-to normal vision and hearing

• Current diagnosis of MDD or OCD

Locations
United States
Massachusetts
Massachusetts General Hospital
RECRUITING
Boston
Massachusetts General Hospital
RECRUITING
Charlestown
Contact Information
Primary
Darin Dougherty, MD
ddougherty@mgb.org
6178180730
Time Frame
Start Date: 2021-01-23
Estimated Completion Date: 2025-03-31
Participants
Target number of participants: 60
Treatments
Active_comparator: Deep Brain Stimulation On
We will assess Reward Motivation behavior with Deep Brain Stimulation on.
No_intervention: Deep Brain Stimulation Off
We will assess Reward Motivation behavior with Deep Brain Stimulation off.
Sponsors
Leads: Massachusetts General Hospital

This content was sourced from clinicaltrials.gov