Dependencies of Acoustic Signal and Image Recordings of Phonatory Movement of the Pharyngoesophageal Mucosa in Laryngectomy Patients Using High-speed Video Endoscopy and a Biomechanical Model

Status: Recruiting
Location: See location...
Intervention Type: Device, Behavioral
Study Type: Observational
SUMMARY

Therapy of advanced cancer of the larynx includes excision of the entire larynx. After the removal of the larynx, the pharyngoesophageal segment (PES) is created by reconstruction of the soft tissue of the pharynx and oesophagus, and its vibration creates a replacement voice. High-speed video endoscopy (HSV) is the only method that visualizes and measures vibration of pharyngoesophageal mucosa (PEM) after laryngectomy. Acoustic characteristics of three forms of the rehabilitated voice of laryngectomized persons (oesophageal voice, tracheoesophageal voice using a speech prosthesis and electrolarynx) have been satisfactorily described but, the interdependence of acoustic and visual representations of the phonatory movement of the PES is still insufficiently investigated. In recent years, the development of biomechanical models is created to analyse the vibration of the PES, but still no uniform results have been achieved that would explain whether the parameters obtained from the analysis of the waveform of the PES can be compared with the parameters obtained from the acoustic analysis of the voice of a laryngectomized patients

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:

• laryngectomised patients who completed minimal their 6-month period without disease after surgery and post-operative treatments such as radiotherapy or chemotherapy

• patients with preserved reading skills

• regular presence at follow-up visits

Locations
Other Locations
Croatia
University Hospital Osijek
RECRUITING
Osijek
Contact Information
Primary
Željka Laksar Klarić, M.D.
zeljka.l.klaric@mail.com
+38598666494
Time Frame
Start Date: 2022-08-01
Estimated Completion Date: 2025-05
Participants
Target number of participants: 52
Treatments
Adult laryngectomised patients
Patients who have undergone total laryngectomy and completed minimal their 6-month period without disease after surgery and post-operative treatments such as radiotherapy or chemotherapy
Sponsors
Collaborators: Josip Juraj Strossmayer University of Osijek
Leads: Osijek University Hospital

This content was sourced from clinicaltrials.gov