Pericapsular Nerve Group Block Mitigates Surgical Stress and Enhances Analgesia in Total Hip Arthroplasty: A Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This randomized controlled trial evaluates the effect of ultrasound-guided Pericapsular Nerve Group (PENG) block on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SII, calculated as platelet × neutrophil / lymphocyte count, is used as a composite marker of perioperative inflammatory and immune response. The study investigates whether PENG block attenuates the systemic inflammatory reaction to surgical trauma compared to sham block.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 100
Healthy Volunteers: f
View:
• Patients with ASA classification I-III
• Aged 65-100 years
• Who will be scheduled for hip arthroplasty under spinal anesthesia
Locations
Other Locations
Poland
Poznan University of Medical Sciences
RECRUITING
Poznan
Time Frame
Start Date: 2026-03-01
Estimated Completion Date: 2026-09-30
Participants
Target number of participants: 60
Treatments
Sham_comparator: Sham blocks
PENG block with 20ml of 0.9% sodium chloride
Active_comparator: PENG block
PENG block with 20ml 0f 0.2% ropivacaine
Related Therapeutic Areas
Sponsors
Leads: Poznan University of Medical Sciences