Route of Dexamethasone Administration in iPACK and ACB for Total Knee Replacement: A Randomized Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The Effect of Dexamethasone Administration Route on Pain and Inflammatory Response in iPACK With ACB for Total Knee Arthroplasty - written in plain language according to ClinicalTrials.gov standards: The goal of this clinical trial is to learn how the route of dexamethasone administration (either through the vein or nerve block) affects pain and inflammation in people having total knee replacement surgery. All participants will receive two types of nerve blocks before surgery: an iPACK block and an adductor canal block (ACB), which help control pain after the operation. The main questions the study aims to answer are: Does injecting dexamethasone into the nerve block reduce pain more effectively than giving it by vein? Which method leads to a lower inflammatory response after surgery? Researchers will compare the two groups to see which route offers better pain relief and less swelling after knee surgery. Participants will: Be randomly assigned to receive dexamethasone either in the nerve block or by IV Receive standard care for total knee replacement Rate their pain and have blood tests after surgery to measure inflammation

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 100
Healthy Volunteers: f
View:

• patients scheduled for total knee arthroplasty

• patients aged \>65 and \<100 years

• patients can provide informed consent

• patients can reliably report symptoms to the research team

Locations
Other Locations
Poland
Poznan University of Medical Sciences
RECRUITING
Poznan
Contact Information
Primary
Malgorzata Reysner, MD PhD
mreysner@ump.edu.pl
+48618738303
Backup
Grzegorz Kowalski, MD PhD
+48618738313
Time Frame
Start Date: 2025-09-01
Estimated Completion Date: 2025-10-30
Participants
Target number of participants: 90
Treatments
Placebo_comparator: Control
iPACK block with ACB
Active_comparator: iv DEX
iPACK block with ACB + iv Dexamethasone
Active_comparator: pn DEX
iPACK block with ACB + perineural Dexamethasone
Sponsors
Leads: Poznan University of Medical Sciences

This content was sourced from clinicaltrials.gov