Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adults ≥18 years undergoing primary TKA for osteoarthritis.
• Cognitively normal and able to self-assess pain and function.
• Provide written informed consent.
Locations
Other Locations
Greece
Attikon University General Hospital
RECRUITING
Athens
Contact Information
Primary
Dimitrios Filippiadis, MD, PhD, EBIR, MSc
dfillipiadis@yahoo.gr
+306948513104
Backup
Vasileios Balomenos, MD, MSc, PhD(c)
balomenosv@gmail.com
+30645297496
Time Frame
Start Date: 2026-01-02
Estimated Completion Date: 2028-03-31
Participants
Target number of participants: 100
Treatments
Other: Cryoneurolysis + TKA Arm
CT-guided cryoneurolysis of upper medial, upper lateral, and lower medial genicular nerves ≥24 hours before TKA.
No_intervention: Control Arm
Standard total knee arthroplasty without preoperative cryoneurolysis.
Related Therapeutic Areas
Sponsors
Leads: Attikon Hospital