• Unilateral lower extremity DVT occlusion involving iliac and/or common femoral veins with up to 2 cm extension in the inferior vena cava (IVC) or femoral in combination with iliac veins, including patients with extension of clot into the contralateral common iliac vein Note: Patients with non-iliofemoral DVT in the contralateral limb, who do not require endovascular treatment, may be enrolled

• Acute thrombotic or thromboembolic occlusion with symptom duration of 14 days or less at presentation

• Frontline treatment with Indigo Aspiration System in the target venous segment per Investigator decision

• Patient is ≥18 years of age

• Informed consent is obtained per Institutional Review Board requirements