Efficacy of Surgical Joint Denervation in Painful Digital Osteoarthritis

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Digital osteoarthritis is the second localization of symptomatic osteoarthritis, after the knee. Its cardinal symptoms are particularly intense pain and functional impairment in the case of the erosive form. There is currently no etiological treatment for osteoarthritis. Symptomatic treatments have a modest efficacy, which justifies the search for new treatments. The surgical options are arthrodesis or prosthesis, invasive techniques potentially sources of complications, and finally proposed infrequently given the prevalence of digital osteoarthritis. DECAD is a prospective phase II trial aimed at evaluating the efficacy of surgical joint denervation in painful digital osteoarthritis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years

• Patients with symptomatic digital osteoarthritis according to the criteria of the American College of Rheumatology

• 1 painful PIP joint (Analog digital scale ≥ 4/10) for more than 3 months

• having failed the usual medical treatment for a minimum of 3 months (level 1 analgesics, NSAIDs, infiltrations)

• Signature of informed consent

• patient affiliated to a social security scheme

• knowing how to read French (for the questionnaires)

Locations
Other Locations
France
Rheumatology department Saint-Antoine Hospital
RECRUITING
Paris
Contact Information
Primary
Adeline CAMBON-BINDER, MD PhD
adeline.cambonbinder@aphp.fr
685573795
Backup
Jérémie SELLAM
jeremie.sellam@aphp.fr
+ 33 1 49 28 25 20
Time Frame
Start Date: 2023-06-05
Estimated Completion Date: 2026-06-15
Participants
Target number of participants: 19
Treatments
Experimental: Surgical denervation
It consists of a section of the nerve branches destined for the PIPJ, coming from the digital collateral nerves as well as the dorsal sensory branches of the radial and ulnar nerves respectively for the index and fifth fingers.
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov