Rehearsal-Induced Memory Consolidation and Its Modulation by Sleep in People With Epilepsy

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, and where sleep may exacerbate epileptic activity. The CORESOM-EPI study aims to compare the effects of rehearsal and sleep on memory consolidation in patients undergoing video-EEG monitoring. Participants will learn object-place associations under two conditions (single versus repeated encoding), with memory tested immediately and again after a 12-hour delay. This delay will either include a full day awake or a night of sleep, allowing direct comparison of sleep- and rehearsal-related consolidation effects. Each participant will perform the task twice, with wake and sleep condition, in a balanced order. As a preliminary phase of the CRIMES study (ANR-DFG 2024), CORESOM-EPI will help assess how sleep and rehearsal influence memory consolidation in epilepsy. It will also serve to adapt the behavioral task for clinical use, paving the way for a future intracranial EEG investigations that will explore the neural networks involved and their modulation by epileptic activity.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Patient with epilepsy (any type of epilepsy)

• Hospitalized for video-EEG recording lasting at least 4 days

• Aged 18-65 years

Locations
Other Locations
France
Service de neurologie fonctionnelle et d'épileptologie, Hôpital neurologique Pierre Wertheimer
RECRUITING
Bron
Contact Information
Primary
Laure PETER-DEREX, Professor
laure.peter-derex@chu-lyon.fr
+334 72 07 17 69
Backup
Sylvain Rheims, Professor
sylvain.rheims@chu-lyon.fr
+334 72 45 79 00
Time Frame
Start Date: 2025-06-30
Estimated Completion Date: 2026-07
Participants
Target number of participants: 20
Treatments
WAKE - SLEEP
This group will start with the condition 1 wake (encoding+immediate recall in the morning (8 :00am) and delayed recall in the evening (8 :00pm)) and will end with the condition 2 sleep : (encoding+immediate recall in the evening (8 :00pm) and delayed recall in the morning (8 :00am))
SLEEP-WAKE
This group will start with the condition 2 sleep and will end with the condition 1 wake
Related Therapeutic Areas
Sponsors
Leads: Hospices Civils de Lyon

This content was sourced from clinicaltrials.gov

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