Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information. Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group. Primary purpose: To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the severe group, compared to the benign group and the control group. Secondary purposes: * to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture

Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Maximum Age: 13
Healthy Volunteers: f
View:

‣ Principal:

⁃ normal psychomotor development

⁃ informed consent signed by both parents and subject if able

⁃ affiliated to social security regimen

‣ Specific

‣ Patients from severe and benign groups:

⁃ focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)

⁃ children hospitalized for their follow-up

⁃ normal neuroimaging

‣ Control group

• children hospitalized for a non neurologic disease

Locations
Other Locations
France
Hopital D'Enfants Pediatrie Medicale Ambulatoire
RECRUITING
Nancy
Hopital de Hautepierre-Service de Pediatrie/Neurologie
RECRUITING
Strasbourg
Contact Information
Primary
Anne DE SAINT MARTIN, MD
anne.desaintmartin@chru-strasbourg.fr
+ 33 3.88.12.83.98
Backup
Lucille SCHNEIDER
lucille.schneider@chru-strasbourg.fr
Time Frame
Start Date: 2019-03-27
Estimated Completion Date: 2027-09
Participants
Target number of participants: 95
Treatments
Experimental: EPILEPSY GROUP
Patients with typical BECTS (benign group) or atypical BECTS or ECSWS (severe group)~Medical visit~Neuropsychological testing~Neuropsychological procedure~Video EEG and polysomnography (standard of care procedure): 2h wake and whole night~Sleep diary
Other: CONTROL GROUP
Patients hospitalized for non neurologic illness (diabetes, nephropathy, chronic intestinal disease)~Medical visit~Neuropsychological testing~Neuropsychological procedure~Video EEG and polysomnography : 2h wake and whole night~Sleep diary
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Strasbourg, France

This content was sourced from clinicaltrials.gov