Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type (AN-BP), 63 bulimia nervosa (BN)) and 63 healthy controls (HC) aged 18-39. Aim 1: To examine neural differences in 'liking' and 'wanting' in ED relative to HC. Aim 2: To examine differences in instrumental learning for reward and punishment in ED relative to HC. Aim 3: To examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later. Exploratory Aim: To explore the associations of dopamine function, as measured by neuromelanin MRI (NM-MRI), with ED diagnosis and brain response to 'liking', 'wanting', and learning.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 39
Healthy Volunteers: t
View:

⁃ Eating Disorder Group:

• Between the ages of 18 and 39 years old

• Meet DSM-V criteria for AN-R, AN-BP, or BN

⁃ Healthy Control Group:

• Between the ages of 18 and 39 years old

• Have maintained 85% to 120% ideal body weight since menarche

Locations
United States
California
UCSD Eating Disorders Treatment and Research Program
RECRUITING
La Jolla
Contact Information
Primary
Christina Wierenga
cwierenga@health.ucsd.edu
858-534-8047
Time Frame
Start Date: 2022-05-26
Estimated Completion Date: 2027-01
Participants
Target number of participants: 252
Treatments
AN-R
Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa restricting subtype.
AN-BP
Participants that meet DSM-V criteria for Anorexia Nervosa binging/purging subtype
BN
Participants that meet DSM-V criteria for Bulimia Nervosa.
Healthy Controls
Participants that do not meet DSM-V criteria for any disorder.
Related Therapeutic Areas
Sponsors
Leads: University of California, San Diego

This content was sourced from clinicaltrials.gov