Avoidance-driven Decision Making and Learning in Anorexia Nervosa and Bulimia Nervosa

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The purpose of this study is to investigate areas of the brain responsible for avoidance learning in adults with eating disorders using brain imaging techniques, computer tasks, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 78 women with an eating disorder (26 with anorexia nervosa \[AN\], 26 with bulimia nervosa \[BN\]) and 26 healthy controls (HC) aged 18-39. Aim 1: Evaluate behavioral differences in active and passive avoidance learning in eating disorders and associations with symptoms. Aim 2: Evaluate whether corticostriatal and limbic-prefrontal fMRI BOLD response associated with avoidance learning differs in eating disorders relative to healthy controls and relates to symptoms. Aim 3: Evaluate whether functional connectivity of avoidance learning neural circuity differs in eating disorders relative to healthy controls.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 39
Healthy Volunteers: t
View:

⁃ Eating Disorder Group:

• Between the ages of 18 and 39 years old

• Meet DSM-V criteria for anorexia nervosa or bulimia nervosa

⁃ Healthy Controls:

• Between the ages of 18 and 39 years old

• Have maintained 85% to 120% ideal body weight since menarche

Locations
United States
California
UCSD Eating Disorders Treatment and Research Program
RECRUITING
La Jolla
Contact Information
Primary
Christina E Wierenga, PhD
cwierenga@health.ucsd.edu
858-534-8047
Time Frame
Start Date: 2024-08-01
Estimated Completion Date: 2027-07-31
Participants
Target number of participants: 78
Treatments
Anorexia Nervosa
Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa.
Bulimia Nervosa
Participants that meet DSM-V criteria for Bulimia Nervosa.
Healthy Controls
Participants that do not meet DSM-V criteria for any disorder.
Related Therapeutic Areas
Sponsors
Leads: University of California, San Diego

This content was sourced from clinicaltrials.gov