Creation of a Digital Twin for Predicting the Progression of Patients With Chronic Thoracic Aortic Dissection

Status: Recruiting
Location: See location...
Intervention Type: Other, Biological
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Aortic dissection causes a tear in the inner layers of the aorta, leading to the formation of a true and false lumen. There are two types of dissection: type A, which affects the ascending aorta, and type B, which affects the descending aorta. Type A aortic dissection is almost always a surgical emergency and involves replacing the ascending aorta with a prosthesis. After this type of dissection, a residual dissection remains in the descending aorta, known as residual type B dissection, which becomes chronic. This requires increased monitoring by MRI or CT scan, which are currently not effective enough to predict the development of an aneurysm that could lead to aortic rupture requiring surgical intervention. Other factors such as blood flow, the forces and mechanisms regulating blood circulation, the mechanics and histology of the aorta, and blood markers could provide a more reliable prediction of the development of an aneurysm. The creation of a digital twin model incorporating all these factors should enable better patient management.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Person who has given written consent

• Age \> 18 years

• Patient with type A aortic dissection with surgical indication for replacement

• Patient with chronic type B aortic dissection, monitored and managed medically, not operated on

Locations
Other Locations
France
Chu Dijon Bourgogne
RECRUITING
Dijon
Contact Information
Primary
Alain Lalande
alain.lalande@u-bourgogne.fr
Time Frame
Start Date: 2025-11-25
Estimated Completion Date: 2031-11
Participants
Target number of participants: 400
Treatments
Experimental: Type B aortic dissection
Experimental: Residual type B aortic dissection following surgery for type A aortic dissection
Sponsors
Leads: Centre Hospitalier Universitaire Dijon

This content was sourced from clinicaltrials.gov