Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions
Who is this study for? Patients with premature ventricular contractions
What treatments are being studied? Adenosine
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:
• Diagnosis of premature ventricular contractions (PVCs)
• Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs
• Male or female between the ages of 18 and 70 years
• Capable of giving informed consent
Locations
United States
New York
Weill Cornell Medicine
RECRUITING
New York
Contact Information
Primary
James E Ip, M.D
jei9008@med.cornell.edu
212 746 2158
Backup
Dolores T Reynolds, BSN
dtr2001@med.cornell.edu
212 746 4617
Time Frame
Start Date: 2017-02-13
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 100
Treatments
Other: Adenosine/ Verapamil Arm
Adenosine: 0.84 mg/kg IV (140 mcg/kg/minute IV for 6 minutes) Verapamil: 0.15 mg/kg IV~Adenosine is known to terminate ventricular arrhythmias that are due to triggered activity (ref Lerman). To study the effects of adenosine on PVC, the investigators will administer Verapamil to slow down the heart initially and adenosine after catheters are introduced to patients who are being treated for symptomatic PVC and have consented to treatment with an invasive electrophysiology study and catheter ablation.
Related Therapeutic Areas
Sponsors
Leads: Weill Medical College of Cornell University